22865-59-4

Basic information

• Product Name: Benzene, 1-methoxy-4-[(4-nitrophenyl)methyl]-
• CAS NO: 22865-59-4
• Molecular Formula: C14H13NO3
• Molecular Weight: 243.262
• Mol File: 22865-59-4.mol
• Article Data: 15

Chemical Properties

• CAS DataBase Reference: Benzene, 1-methoxy-4-[(4-nitrophenyl)methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-methoxy-4-[(4-nitrophenyl)methyl]-(22865-59-4)
• EPA Substance Registry System: Benzene, 1-methoxy-4-[(4-nitrophenyl)methyl]-(22865-59-4)

Safety Data

• Hazardous Substances Data: 22865-59-4(Hazardous Substances Data)

Upstream product

• 100-14-1 4-nitrobenzyl chloride 
• 70744-47-7 (p-methoxyphenyl)tri-n-butylstannane 
• 19824-21-6 C₁₀H₁₅N₂O₂⁽¹⁺⁾*Br^(1-) 
• 5720-07-0 4-methoxyphenylboronic acid 
• 842-58-0 (4-methoxyphenyl)(4-nitrophenyl)methanol 
• 24067-17-2 4-nitrophenylboronic acid 
• 123-11-5 4-methoxy-benzaldehyde 
• 104-03-0 4-nitrobenzeneacetic acid 
• 22690-86-4 [Cu(para-nitrophenyl acetate)₂]_n 
• 213596-33-9 2-(4-methoxyphenyl)-5,5-dimethyl-1,3,2-dioxaborolane 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 586-78-7 para-nitrophenyl bromide 
• 78782-17-9 4,4,5,5-tetramethyl-2-[(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methyl]-1,3,2-dioxaborolane 
• 619-73-8 4-nitrobenzyl chloride 

Downstream Products

• 1151-94-6 4-methoxy-4'-nitrobenzophenone 
• 21969-07-3 4-(4-nitrobenzyl)phenol 

Relevant articles and documents

Cross coupling of benzylammonium salts with boronic acids using a well-defined N-heterocyclic carbene-palladium(ii) precatalyst

N-heterocyclic carbene-palladium(ii)-catalyzed cross-coupling of benzylammonium salts with arylboronic acids for the synthesis of diarylmethane derivatives via C-N bond activation has been developed. Notably, in the presence of the easily prepared and bench-stable Pd-PEPPSI precatalyst, the Csp3-N bond activation of the benzylammonium salt even proceeded smoothly in isopropanol at room temperature.

An Efficient Ga(OTf)3/Isopropanol Catalytic System for Direct Reduction of Benzylic Alcohols

This study aims to report the first gallium-catalyzed direct reduction of benzylic alcohols using isopropanol as a reductant. The reaction proceeds via gallium catalyst-assisted hydride transfer of the in situ-generated benzylic isopropyl ether. The method generates only water and acetone as byproducts and thus provides an atom-economic and environmentally friendly approach to the synthesis of di- and triarylmethanes, which are important substructures in various bioactive compounds and functional materials. (Figure presented.).

Picolinamide modified β-cyclodextrin/Pd (II) complex: Asupramolecular catalyst for Suzuki-Miyaura coupling of aryl, benzyl and allyl halides with arylboronic acids in water

Novel supramolecular catalysts for Suzuki-Miyaura coupling were prepared and characterized by NMR, FT-IR, TEM, XRD, TGA, and XPS. The resulting picolinamide-modified β-cyclodextrin/Pd(II) complex (Pd(II)@PCA-β-CD) showed very efficient catalytic activity for Suzuki-Miyaura coupling of aryl, benzyl, and allyl halides with arylboronic acids in an environmentally benign aqueous solution. Various organic halides including chlorides can produce good to excellent yields with phenyl-boronic acid and a catalytic amount of Pd(II)@PCA-β-CD. This hydro-soluble catalyst was capable of being reused for at least eight runs with only a slight loss of catalytic activity. A putative mechanism of the Pd(II)/Pd(IV) catalytic cycle was also explored and calculated by ab initio QM/MM methods.