1151-94-6

Basic information

• Product Name: 4-METHOXY-4'-NITROBENZOPHENONE
• Synonyms: 4-METHOXY-4'-NITROBENZOPHENONE;4-Methoxy-4´-nitrobenzophenone;NSC406625
• CAS NO: 1151-94-6
• Molecular Formula: C₁₄H₁₁NO₄
• Molecular Weight: 257.24
• Mol File: 1151-94-6.mol
• Article Data: 62

Chemical Properties

• Melting Point: 125-127°C
• Boiling Point: 435.3°Cat760mmHg
• Flash Point: 197.9°C
• Appearance: /
• Density: 1.264g/cm³
• CAS DataBase Reference: 4-METHOXY-4'-NITROBENZOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-METHOXY-4'-NITROBENZOPHENONE(1151-94-6)
• EPA Substance Registry System: 4-METHOXY-4'-NITROBENZOPHENONE(1151-94-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 1151-94-6(Hazardous Substances Data)

Usage

Uses

4-Methoxy-4'-nitrobenzophenone is used as an organic chemical synthesis intermediate.

Preparation

Obtained by reaction of p-nitrobenzoyl chloride with anisole,in the presence of MoO? 2Cl2 (20 mol%) at reflux for 20 h (3%) in the presence of perfluorobutane sulfonic acid in the presence of aluminium chloride in carbon disulfide for 1 h at r.t. (72%) in the presence of MoO? 2Cl2 (20 mol%) at reflux for 20 h (31%).

Upstream product

• 122-04-3 4-nitro-benzoyl chloride 
• 100-66-3 methoxybenzene 
• 24524-95-6 S-(p-nitrobenzoyl)mercaptoethane 
• 36967-86-9 4-Nitrobenzoesaeure-trifluormethansulfonsaeure-anhydrid 
• 22865-59-4 Methyl 4-(4-Nitrobenzyl)phenyl Ether 
• 7446-70-0 aluminium trichloride 
• 18920-70-2 4-hydroxy-4'-nitrobenzophenone 
• 74-88-4 methyl iodide 
• 62-23-7 4-nitro-benzoic acid 
• 33397-21-6 tris(4-methoxyphenyl)bismuth 
• 5720-07-0 4-methoxyphenylboronic acid 
• 555-16-8 4-nitrobenzaldehdye 
• 636-98-6 p-nitrobenzene iodide 
• 201230-82-2 carbon monoxide 

Downstream Products

• 39066-26-7 5-p-methoxybenzoylsalicylonitrile 
• 28358-68-1 1-(4-methoxyphenyl)-1-(4-nitrophenyl)ethylene 
• 94872-05-6 p-Methoxy-p'-nitro-benzophenon-p-tolylimin-(trans) 
• 174004-08-1 (R)-(4-methoxyphenyl)(4-nitrophenyl)methanol 
• 500579-41-9 4-(4-methoxybenzyl)benzenamine 
• 345-89-1 4-fluoro-4'-methoxybenzophenone 
• 97732-63-3 4-(-acetylamino)-4'-methoxybenzophenone 
• 97732-62-2 1-(4-fluorophenyl)-1-(4-hydroxyphenyl)-2-phenyl-1-butene 
• 97732-68-8 4-(piperidinoazo)-4'-methoxybenzophenone 
• 97732-65-5 1-<4-(acetylamino)phenyl>-1-(4-hydroxyphenyl)-2-phenyl-1-butene 
• 97732-64-4 1-<4-(acetylamino)phenyl>-1-(4-methoxyphenyl)-2-phenyl-1-butene 
• 97732-60-0 (E)-1-(4-fluorophenyl)-1-(4-methoxyphenyl)-2-phenyl-1-butene 
• 97732-61-1 (Z)-1-(4-fluorophenyl)-1-(4-methoxyphenyl)-2-phenyl-1-butene 
• 77588-48-8 (Z)-Fluorotamoxifen 

Relevant articles and documents

Highly selective catalytic Friedel-Crafts acylation and sulfonylation of activated aromatic compounds using indium metal

The Friedel-Crafts acylation of activated benzenes with various aromatic and aliphatic acid chlorides was studied in the presence of indium metal. The reaction was accomplished in high isolated yields under solvent or solvent-less conditions. The method is also applicable for preparing diaryl sulfones from aromatic compounds and aryl sulfonyl chlorides.

Liquid-Phase Total Synthesis of Plecanatide Aided by Diphenylphosphinyloxyl Diphenyl Ketone (DDK) Derivatives

Plecanatide is an oral guanylate cyclase-C agonist for the treatment of gastrointestinal disorders. The large-scale supply of plecanatide is restrained primarily by its industrial manufacture. Herein we developed diphenylphosphinyloxyl diphenyl ketone (DD

Recyclable polyetheretherketone fiber-supported N-heterocyclic carbene catalysts for nucleophilic acylation of fluorobenzenes

We report for the first time a novel support of polyetheretherketone fiber for the synthesis of recyclable N-heterocyclic carbene (NHC) catalysts. The fiber catalysts were verified in nucleophilic acylation of fluorobenzenes with superior catalytic activities, and successfully recycled by a tiny pair of tweezers over 21 cycles with minimal loss of performance.

Novel and efficient bridged bis(N-heterocyclic carbene)palladium(II) catalysts for selective carbonylative Suzuki–Miyaura coupling reactions to biaryl ketones and biaryl diketones

Bridged N,N′-substituted bisbenzimidazolium bromide salts (L1, L2, and L3) were synthesized and fully characterized. Reactions of palladium acetate with L1, L2, and L3 afforded corresponding new bridged bis(N-heterocyclic carbene)palladium(II) complexes (C1, C2, and C3) in high yields. The X-ray structure of complex C1 showed that the Pd(II) ion is bonded to the two carbon atoms of the bis(N-heterocyclic carbene) and two bromido ligands are in the cis position, resulting in a distorted square planar geometry. The three Pd(NHC)2Br2 complexes C1, C2, and C3 were evaluated in carbonylative Suzuki–Miyaura coupling reactions of aryl boronic acids with aryl halides and displayed high catalytic activity with low catalyst loading. The coupling reactions of aryl bromides were selective towards the carbonylation product at higher carbon monoxide pressure.