22966-26-3

Basic information

• Product Name: 1-(3-bromophenyl)-3-phenylprop-2-en-1-one
• CAS NO: 22966-26-3
• Molecular Formula: C₁₅H₁₁BrO
• Molecular Weight: 287.1512
• Mol File: 22966-26-3.mol
• Article Data: 19

Chemical Properties

• Boiling Point: 403.4°C at 760 mmHg
• Flash Point: 83.2°C
• Density: 1.393g/cm³
• Vapor Pressure: 1.02E-06mmHg at 25°C
• Refractive Index: 1.646
• CAS DataBase Reference: 1-(3-bromophenyl)-3-phenylprop-2-en-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-bromophenyl)-3-phenylprop-2-en-1-one(22966-26-3)
• EPA Substance Registry System: 1-(3-bromophenyl)-3-phenylprop-2-en-1-one(22966-26-3)

Safety Data

• Hazardous Substances Data: 22966-26-3(Hazardous Substances Data)

Usage

Appearance

Yellow solid

Usage

Commonly used in organic synthesis and pharmaceutical research

Chemical structure

Ketone derivative containing a bromophenyl group and a phenylpropenone group

Applications

a. Reactant in the synthesis of various biologically active compounds
b. Potential anti-inflammatory properties
c. Potential antitumor properties
d. Development of new synthetic methodologies
e. Preparation of complex molecules for medicinal purposes

Upstream product

• 100-52-7 benzaldehyde 
• 2142-63-4 1-(3-Bromophenyl)ethanone 
• 3132-99-8 m-bromobenzoic aldehyde 
• 98-86-2 acetophenone 
• 100-51-6 benzyl alcohol 
• 52780-14-0 1-(3-bromophenyl)ethanol 
• 100-42-5 styrene 
• 201230-82-2 carbon monoxide 
• 66107-31-1 3-bromophenyl trifluoromethanesulfonate 
• 278168-68-6 1-(3-bromophenyl)-3-phenylprop-2-yn-1-ol 
• 536-74-3 phenylacetylene 
• 140-10-3 (E)-3-phenylacrylic acid 
• 7194-78-7 (3-bromophenyl)oxoacetic acid 

Downstream Products

• 105065-87-0 rac-(E)-1-(3-bromophenyl)-3-phenylprop-2-en-1-ol 
• 133131-50-7 4-(3-bromo-phenyl)-4-oxo-2-phenyl-butyronitrile 
• 1061342-82-2 C₁₆H₁₄BrN₃S 
• 539857-07-3 C₂₁H₁₉BrO₃ 
• 1357912-55-0 (3-bromophenyl)((2R,3S,4S)-4-hydroxy-2-phenyltetrahydrothiophen-3-yl)methanone 
• 1393743-55-9 (E)-3-(3-(3-bromophenyl)-1-phenylallyl)-1H-indole 
• 1393743-54-8 (E)-3-(1-(3-bromophenyl)-3-phenylallyl)-1H-indole 
• 1393743-22-0 (E)-1-(3-bromophenyl)-3-phenylallyl acetate 
• 1393743-23-1 (E)-3-(3-bromophenyl)-1-phenylallyl acetate 
• 1393743-33-3 (E)-2-(3-(3-bromophenyl)-1-phenylallyl)-5-methylfuran 
• 1393743-32-2 (E)-2-(1-(3-bromophenyl)-3-phenylallyl)-5-methylfuran 
• 1393743-70-8 (E)-2-(1-(3-bromophenyl)-3-phenylallyl)-5-methylthiophene 
• 1393743-71-9 (E)-2-(3-(3-bromophenyl)-1-phenylallyl)-5-methylthiophene 
• 1224869-09-3 C₂₇H₂₂BrO₂P 

Relevant articles and documents

Selective C-C bonds formation, N-alkylation and benzo[d]imidazoles synthesis by a recyclable zinc composite

Earth abundant metals are much less expensive, promising, valuable metals and could be served as catalysts for the borrowing hydrogen reaction, dehydrogenation and heterocycles synthesis, instead of noble metals. The uniformly dispersed zinc composites were designed, synthesized and carefully characterized by means of XPS, EDS, TEM and XRD. The resulting zinc composite showed good catalytic activity for the N-alkylation of amines with amines, ketones with alcohols in water under base-free conditions, while unsaturated carbonyl compounds could also be synthesized by tuning the reaction conditions. Importantly, it was the first time to realize the synthesis of 2-aryl-1H-benzo[d]imidazole derivatives by using this zinc composite under green conditions. Meanwhile, this zinc catalyst could be easily recovered and reused for at least five times.

Green method for high-selectivity synthesis of chalcone compounds

Under the condition of air, the water-soluble inorganic weak base is used as a catalyst to catalyze the hydrogen transfer reaction of the propargyl alcohol compound, so that the green synthesis of the high-trans selective chalcone compound is realized. Reaction temperature: 80 - 120 °C and reaction time 12 - 48 hours. To the technical scheme, any transition metal catalyst and ligand do not need to be used, inert gas protection is not needed, no other byproducts are generated, the atom economy 100%, green and environment friendliness are avoided, and the product is a high-selectivity (E)-type product. The reaction conditions are relatively low in requirement. Compared with the prior art, the alkali catalyst is obvious in advantages, and has a certain application prospect in the fields of organic synthesis, biochemistry, medicine and the like.

Studies of NMR Chemical Shifts of Chalcone Derivatives of Five-membered Monoheterocycles and Determination of Aromaticity Indices

A series of the chalcone derivatives of the five-membered monoheterocyclic compounds, (E)-1-aryl-3-heteroarylpropen-1-ones, were prepared by aldol condensation of the corresponding aldehydes of thiophene, pyrrole, and furan with m- and p-substituted acetophenones. Similar condensation of the acetyl compounds of the heterocycles with m- and p-substituted benzaldehydes gave another series of the chalcone derivatives, (E)-1-heteroaryl-3-arylpropen-1-ones. The 13C chemical shift values (δC) of the chalcone derivatives were determined in order to find if they correlated with the Hammett σ values. A good correlation, especially for the β-C for both series, was found for the 13C chemical shift values (δC) of the chalcone derivatives with the Hammett σ values. The chemical shift values of the β-C of the heterocyclic compounds were plotted against those of the benzene derivatives. The resulting slopes were found to be close to the values of the aromaticity indices.