230615-51-7 Usage
Description
2,3,4,5-Tetrahydro-3-(trifluoroacetyl)-1,5-methano-1H-3-benzazepine is a complex organic compound with a unique molecular structure. It is characterized by its tetrahydro and trifluoroacetyl groups, as well as its 1,5-methano-1H-3-benzazepine core. 2,3,4,5-Tetrahydro-3-(trifluoroacetyl)-1,5-methano-1H-3-benzazepine plays a crucial role in the pharmaceutical industry due to its involvement in the synthesis of specific medications.
Uses
Used in Pharmaceutical Industry:
2,3,4,5-Tetrahydro-3-(trifluoroacetyl)-1,5-methano-1H-3-benzazepine is used as a reactant for the preparation of Varenicline, a nicotinic α4β2 acetylcholine receptor partial agonist. Varenicline is an important medication that aids in smoking cessation by reducing the cravings and withdrawal symptoms associated with nicotine dependence. The compound's role in the synthesis of Varenicline highlights its significance in the development of treatments for tobacco addiction and related health issues.
Check Digit Verification of cas no
The CAS Registry Mumber 230615-51-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,3,0,6,1 and 5 respectively; the second part has 2 digits, 5 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 230615-51:
(8*2)+(7*3)+(6*0)+(5*6)+(4*1)+(3*5)+(2*5)+(1*1)=97
97 % 10 = 7
So 230615-51-7 is a valid CAS Registry Number.
InChI:InChI=1/C13H12F3NO/c14-13(15,16)12(18)17-6-8-5-9(7-17)11-4-2-1-3-10(8)11/h1-4,8-9H,5-7H2
230615-51-7Relevant articles and documents
PROCESS FOR PREPARING VARENICLINE, VARENICLINE INTERMEDIATES, AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF
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Page/Page column 16-17, (2010/04/06)
Provided herein is an improved, convenient, commercially viable and environmentally friendly process for the preparation of varenicline or a pharmaceutically acceptable salt thereof comprising reacting l-(4,5-diamino-10-aza-tricyclo[6.3.1.02 7]dodeca-2(7),3,5-trien- 10-yl)-2,2,2-trifluoro-ethanone with chloroacetaldehyde in the pressence of an oxygen source. Provided further herein is an improved and industrially advantageous process for the preparation of l-(4,5-diamino-10-aza-tricyclo[6.3.1.02 7]dodeca-2(7),3,5-trien-10-yl)-2,2,2- trifluoro-ethanone.
PROCESSES FOR THE PREPARATION OF VARENICLINE AND INTERMEDIATES THEREOF
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Page/Page column 9, (2009/12/28)
The invention provides an improved process for the preparation and purification of Varenicline and intermediates for the preparation of Varenicline.
Process for the preparation of 1,3-substituted indenes and aryl-fused azapolycyclic componunds
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, (2008/06/13)
The present invention relates to processes for the preparation of any of the intermediate 1,3-substituted indenes of the formulae (Ia), (Ib) and (Ic) or a mixture thereof: wherein R1, R2, R3, R4, and R5 are defined herein. Compounds of formulae (Ia), (Ib) and (IC) or mixtures thereof are useful in the preparation of compounds of formula (II): wherein R2, R3 and R6 are also defined herein.