230615-52-8 Usage
Description
2,3,4,5-TETRAHYDRO-1H-1,5-METHANO-3-BENZAZEPINE HYDROCHLORIDE is a chemical compound that serves as a key component in the pharmaceutical industry, particularly in the development of medications aimed at smoking cessation.
Uses
Used in Pharmaceutical Industry:
2,3,4,5-TETRAHYDRO-1H-1,5-METHANO-3-BENZAZEPINE HYDROCHLORIDE is used as an intermediate compound for the preparation of the main band impurity of Varenicline (V098490), a nicotinic α4β2 acetylcholine receptor partial agonist. 2,3,4,5-TETRAHYDRO-1H-1,5-METHANO-3-BENZAZEPINE HYDROCHLORIDE plays a crucial role in the development of medications that aid in smoking cessation, helping individuals overcome nicotine addiction and improve their overall health.
Check Digit Verification of cas no
The CAS Registry Mumber 230615-52-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,3,0,6,1 and 5 respectively; the second part has 2 digits, 5 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 230615-52:
(8*2)+(7*3)+(6*0)+(5*6)+(4*1)+(3*5)+(2*5)+(1*2)=98
98 % 10 = 8
So 230615-52-8 is a valid CAS Registry Number.
InChI:InChI=1/C11H13N.ClH/c1-2-4-11-9-5-8(6-12-7-9)10(11)3-1;/h1-4,8-9,12H,5-7H2;1H
230615-52-8Relevant articles and documents
Preparation method of varenicline key intermediate
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Paragraph 0114-0122, (2019/04/04)
The invention discloses a preparation method of a varenicline key intermediate. A target compound is prepared from indanone by the six steps of halogenation, cyanidation, hydrolysis, closed-loop reaction, reduction and hydrochloride formation. The preparation method has the advantages of easy availability of raw materials, mild reaction conditions, simple process, high yield, low cost, low environmental pollution and good utilization value in industrial production.
PROCESSES FOR THE PREPARATION OF VARENICLINE AND INTERMEDIATES THEREOF
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Page/Page column 9, (2009/12/28)
The invention provides an improved process for the preparation and purification of Varenicline and intermediates for the preparation of Varenicline.