23326-27-4

Basic information

• Product Name: METHYL 2-BUTYNOATE
• Synonyms: TETROLIC ACID METHYL ESTER;METHYL TETROLATE;METHYL 2-BUTYNOATE;2-BUTYNOIC ACID METHYL ESTER;Methyl-2-Butynaote97%;Methyl2-butynoate=Methyltetrolate;Methyl 2-butynoate,97%;Methyl 2-butynoate, 97% 5GR
• CAS NO: 23326-27-4
• Molecular Formula: C₅H₆O₂
• Molecular Weight: 98.1
• Product Categories: Acetylenes;Acetylenic Carboxylic Acids & Their Derivatives
• Mol File: 23326-27-4.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 76-77 °C (80 mmHg)
• Flash Point: 45 °C
• Appearance: Clear colorless to yellow/Liquid
• Density: 0.98
• Vapor Pressure: 6mmHg at 25°C
• Refractive Index: 1.436-1.438
• Storage Temp.: Flammables area
• CAS DataBase Reference: METHYL 2-BUTYNOATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 2-BUTYNOATE(23326-27-4)
• EPA Substance Registry System: METHYL 2-BUTYNOATE(23326-27-4)

Safety Data

• Hazard Codes: Xn
• Statements: 10-36/37/38-20/21/22
• Safety Statements: 16-36/37/39-26
• RIDADR: 1993
• HazardClass: 3.2
• PackingGroup: III
• Hazardous Substances Data: 23326-27-4(Hazardous Substances Data)

Usage

Description

METHYL 2-BUTYNOATE, also known as an alkynoate, is a clear colorless to yellowish liquid with unique chemical properties. It is a versatile compound that serves as a key intermediate in the synthesis of various organic molecules.

Uses

Used in Pharmaceutical Industry:
METHYL 2-BUTYNOATE is used as a synthetic intermediate for the preparation of phenanthrenes and benzoindolyl carboxylates, which are important compounds in the development of pharmaceuticals. These compounds have potential applications in the treatment of various diseases and disorders.
Used in Chemical Synthesis:
METHYL 2-BUTYNOATE is used as a key building block in the synthesis of a wide range of organic compounds, including pharmaceuticals, agrochemicals, and specialty chemicals. Its unique structure and reactivity make it a valuable asset in the development of new and innovative products.
Used in Research and Development:
METHYL 2-BUTYNOATE is employed as a research compound in academic and industrial laboratories, where it is used to explore new reaction pathways and develop novel synthetic methods. Its versatility and unique properties make it an essential tool in the advancement of chemical science and technology.

Synthesis Reference(s)

Synthesis, p. 1100, 1982 DOI: 10.1055/s-1982-30090

InChI:InChI=1/C5H6O2/c1-3-4-5(6)7-2/h1-2H3

Upstream product

• 67-56-1 methanol 
• 590-93-2 2-Butynoic acid 
• 4344-87-0 1,2-dihydro-5-methyl-3H-pyrazol-3-one 
• 108-26-9 3-methyl-2-pyrazoline-5-one 
• 201230-82-2 carbon monoxide 
• 74-99-7 prop-1-yne 
• 79-22-1 methyl chloroformate 
• 186581-53-3 diazomethane 
• 1743-62-0 [acetyl(methoxycarbonyl)methylene]triphenylphosphorane 

Downstream Products

• 102369-53-9 2,6-dimethyl-cyclohexa-1,4-dienecarboxylic acid 
• 57826-17-2 4-(methoxycarbonyl)-1(E)-phenyl-1,4,5-hexatrien-3-ol 
• 34603-26-4 trans,trans-3,7-Dimethyl-deca-2,6-diensaeuremethylester 
• 55546-61-7 methyl (Z)-3-(phenylthio)but-2-enoate 
• 50983-22-7 1-Carbomethoxy-2-methylcyclohexa-1,4-dien 
• 25113-27-3 5-methyl-1,3-diphenyl-1H-pyrazole-4-carboxylic acid methylester 
• 25113-25-1 1,3-Diphenyl-4-methyl-pyrazol-5-carbonsaeure-methylester 
• 151101-22-3 4-benzyloxy-(E)-but-2-enoic acid methyl ester 
• 159693-09-1 3-(4-Fluoro-phenyl)-5-methyl-isoxazole-4-carboxylic acid methyl ester 
• 163593-66-6 Dimethyl 3-cyclopentene-1,3-dicarboxylate 
• 54238-27-6 methyl (E)-4-(1,3-dioxoisoindolin-2-yl)but-2-enoate 
• 4525-27-3 β-acetoxy-crotonic acid methyl ester 
• 207225-49-8 2-butynoic acid (-)-menthol ester 
• 190272-46-9 methyl 2-(4-chlorophenyl)-1-tosyl-2,5-dihydro-1H-pyrrole-3-carboxylate 

Relevant articles and documents

Oxidative Methoxycarbonylation of Allene in the Presence of a Copper-Palladium Catalyst

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The detection of PHIP effects allows new insights into the mechanism of olefin isomerisation during catalytic hydrogenation

PHIP (parahydrogen-induced polarisation) effects in the 1H NMR spectra of the products of Rh-complex-catalysed alkyne hydrogenation brings to light the fact that the cis-trans isomerisation of the formed olefin occurs through the formation of a σ-bonded intermediate stabilised by the reversible addition of a hydrogen molecule at the metal centre. Wiley-VCH Verlag GmbH & Co. KGaA, 2008.

Copper-Catalyzed Domino Synthesis of Benzo[4,5]imidazo[1,2-a]pyrimidin-4(10H)-ones using Cyanamide as a Building Block

An efficient and practical copper-catalyzed domino synthesis of benzo[4,5]imidazo[1,2-a]pyrimidin-4(10H)-ones has been developed. The protocol uses N-(2-halophenyl)-3-alkylpropiolamides and cyanamide as the starting materials, inexpensive copper(I) iodide and pipecolinic acid as the catalyst and ligand, and the corresponding products were obtained in moderate to good yields.

Synthesis and spectroscopic characterization of 1-13C- and 4-13C-plastoquinone-9

This paper presents the synthesis of 1-13C- and 4-13C-plastoquinone-9 and their characterization with NMR spectroscopy and mass spectrometry. The synthetic scheme has been further adapted to introduce 13C-labeled plastoquinones on all individual and on each combination of positions in the quinone ring. Also a two-step scheme is disclosed to prepare unlabeled plastoquinone-9. Wiley-VCH Verlag GmbH, 69451 Weinheim, Germany, 2002.