23363-91-9

Basic information

• Product Name: N-(2-HYDROXYETHYL)BUTANAMIDE
• Synonyms: N-(2-HYDROXYETHYL)BUTANAMIDE
• CAS NO: 23363-91-9
• Molecular Formula: C₆H₁₃NO₂
• Molecular Weight: 131.1729
• Mol File: 23363-91-9.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 315.4°Cat760mmHg
• Flash Point: 144.5°C
• Appearance: /
• Density: 1.001g/cm³
• Vapor Pressure: 3.74E-05mmHg at 25°C
• Refractive Index: 1.446
• CAS DataBase Reference: N-(2-HYDROXYETHYL)BUTANAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-HYDROXYETHYL)BUTANAMIDE(23363-91-9)
• EPA Substance Registry System: N-(2-HYDROXYETHYL)BUTANAMIDE(23363-91-9)

Safety Data

• Hazardous Substances Data: 23363-91-9(Hazardous Substances Data)

Usage

InChI:InChI=1/C6H13NO2/c1-2-3-6(9)7-4-5-8/h8H,2-5H2,1H3,(H,7,9)

Upstream product

• 141-43-5 ethanolamine 
• 105-54-4 butanoic acid ethyl ester 
• 541-35-5 butanamide 
• 141-75-3 butyryl chloride 
• 106-31-0 butanoic acid anhydride 
• 107-92-6 butyric acid 

Downstream Products

• 13670-37-6 2-(1-phenylcarbamoyl-propylidene)-oxazolidine-3-carboxylic acid anilide 
• 1356550-53-2 2-(4-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-ylcarbamoyl)benzamido)ethyl butyrate 
• 23185-09-3 2-propyl-2-thiazoline 
• 4694-80-8 2-n-propyl-2-oxazoline 

Relevant articles and documents

Hydrogen bond organocatalysis of benzotriazole in transamidation of carboxamides with amines

A new method of transamidation of carboxamides with amines catalyzed by benzotriazole has been developed.

Alkyl sulfonyl derivatized PAMAM-G2 dendrimers as nonviral gene delivery vectors with improved transfection efficiencies

Amphiphilic dendrimer-based gene delivery vectors bearing peripheral alkyl sulfonyl hydrophobic tails were constructed using low-generation PAMAM-G2 as the core and functionalized by means of the aza-Michael type addition of its primary amino groups to vinylsulfone derivatives as an efficient tool for surface engineering. While the unmodified PAMAM-G2 was unable to efficiently transfect eukaryotic cells, functionalized PAMAM-G2 dendrimers were able to bind DNA at low N/P ratios, protect DNA from digestion with DNase I and showed high transfection efficiencies and low cytotoxicity. Dendrimers with a C18 alkyl chain produced transfection efficiencies up to 3.1 fold higher than LipofectAMINE 2000 in CHO-k1 cells. The dendriplexes based in functionalized PAMAM-G2 also showed the ability to retain their transfection properties in the presence of serum and the ability to transfect different eukaryotic cell lines such as Neuro-2A and RAW 264.7. Taking advantage of the vinylsulfone chemistry, fluorescent PAMAM-G2 derivatives of these vectors were prepared as molecular probes to determine cellular uptake and internalization through a clathrin-independent mechanism.

Dipeptide alcohol-based inhibitors of eukaryotic DNA polymerase α

We reported previously that a novel dipeptide alcohol, l- homoserylaminoethanol (Hse-Gly-ol), is a selective inhibitor of eukaryotic DNA polymerase ε (pol ε) [Bioorg. Med. Chem. 2004, 12, 957-962]. The discovery suggests that the dipeptide structure could