23616-32-2

Basic information

• Product Name: 5-CHLORO-1,6-NAPHTHYRIDINE
• Synonyms: 5-Chloro-[1,6]naphthyridi...;1,6-Naphthyridine,5-chloro-
• CAS NO: 23616-32-2
• Molecular Formula: C₈H₅ClN₂
• Molecular Weight: 164.6
• Product Categories: CHIRAL CHEMICALS
• Mol File: 23616-32-2.mol
• Article Data: 13

Chemical Properties

• Melting Point: 106-107℃
• Boiling Point: 307.889 °C at 760 mmHg
• Flash Point: 168.825 °C
• Appearance: /
• Density: 1.35 g/cm³
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.663
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 2.04±0.30(Predicted)
• CAS DataBase Reference: 5-CHLORO-1,6-NAPHTHYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-CHLORO-1,6-NAPHTHYRIDINE(23616-32-2)
• EPA Substance Registry System: 5-CHLORO-1,6-NAPHTHYRIDINE(23616-32-2)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 23616-32-2(Hazardous Substances Data)

Usage

General Description

5-CHLORO-1,6-NAPHTHYRIDINE is a chemical compound with the molecular formula C11H6ClN. It belongs to the naphthyridine class of organic compounds and is a chlorinated derivative of 1,6-naphthyridine. 5-CHLORO-1,6-NAPHTHYRIDINE is commonly used as a building block in the synthesis of pharmaceuticals and agrochemicals. It possesses a unique structure with a chloro group attached to the naphthyridine ring, making it a valuable intermediate in organic synthesis. Its properties and reactivity make it an important chemical in the field of medicinal and agricultural chemistry, with potential applications in the development of new drugs and crop protection products.

InChI:InChI=1/C8H5ClN2/c9-8-6-2-1-4-10-7(6)3-5-11-8/h1-5H

Upstream product

• 65719-09-7 methyl 2-methylnicotinate 
• 97308-56-0 2-(2,2-dimethoxy-ethyl)-nicotinamide 
• 97308-52-6 2-(β,β-dimethoxyethyl)-3-pyridinecarbonitrile 
• 97308-49-1 2-trimethylsilylethynyl-3-pyridinecarbonitrile 
• 5860-72-0 7,8-dihydro-5H-pyrano[4,3-b]pyridin-5-one 
• 106837-37-0 2-(2-hydroxy-ethyl)-nicotinic acid amide 
• 23616-31-1 1,6-naphthyridine-5(6H)-one 

Downstream Products

• 13623-84-2 1,2,3,4-tetrahydro-1,6-naphthyridine 
• 1516896-09-5 3-methyl-2-((1S,2S)-2-(quinolin-2-yl)cyclopropyl)-3H-imidazo[4,5-f]quinoline 
• 1516896-06-2 C₂₁H₁₉N₇ 
• 1516895-53-6 trans-2-(2-(5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazin-2-yl)cyclopropyl)-3-methylimidazo[2,1-f][1,6]naphthyridine 
• 23616-35-5 2,5-dichloro-1,6-naphthyridine 
• 1351516-79-4 6-Amino-1,6-naphthyridin-5(6H)-iminium-2,4,6-trimethylbenzenesulfonate 
• 55570-60-0 1,6-naphthyridin-5-amine 
• 253-72-5 1,6-naphthyridine 

Relevant articles and documents

-

-

Preparation method of formaldehyde-substituted aza-condensed ring compound

The invention provides a preparation method of a formaldehyde-substituted aza-condensed ring compound, comprising the following steps: by using an aza-condensed ring lactam compound as a starting material, carrying out halogenation reaction, methylation reaction and methyl oxidation reaction to obtain the formaldehyde-substituted aza-condensed ring compound. According to the preparation method ofthe formaldehyde-substituted aza-condensed ring compound, the whole synthesis route is good in step repeatability, mild in operation condition and high in safety, and large-scale production and industrial popularization are facilitated; post-treatment energy consumption is low, a large amount of toxic wastewater is not generated, no pollution is caused to the environment, the production safety level and the production cost are reduced, application of green and environment-friendly industrial production is facilitated, and wide application prospects are achieved.

Wnt SIGNALING INHIBITOR, COMPOSITION, AND COMPOUND AS USE THEREFOR

PROBLEM TO BE SOLVED: To provide an inhibitor for Wnt signaling route. SOLUTION: The present invention provides a compound represented by formula I, and a composition comprising the compound (X1-X8 independently represent CR4 or N; Y1 is H or C (R4)3; Y2 and Y3 independently represent H, halogen or C (R3)3; R1 and R2 independently represent H, halogen, C1-6 alkyl, quinolinyl or the like; R3s independently represent H, halogen, cyano, C1-6 alkyl or the like; R4s independently represent H, halogen, cyano, C1-6 alkoxy or the like). SELECTED DRAWING: None COPYRIGHT: (C)2017,JPOandINPIT