97308-49-1

Basic information

• Product Name: 2-TRIMETHYLSILANYLETHYNYL-3-CYANOPYRIDINE
• Synonyms: 2-TRIMETHYLSILANYLETHYNYL-3-CYANOPYRIDINE;2-trimethylsilylethynyl-3-pyridinecarbonitrile;2-((triMethylsilyl)ethynyl)nicotinonitrile
• CAS NO: 97308-49-1
• Molecular Formula: C₁₁H₁₂N₂Si
• Molecular Weight: 200.31188
• Mol File: 97308-49-1.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-TRIMETHYLSILANYLETHYNYL-3-CYANOPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-TRIMETHYLSILANYLETHYNYL-3-CYANOPYRIDINE(97308-49-1)
• EPA Substance Registry System: 2-TRIMETHYLSILANYLETHYNYL-3-CYANOPYRIDINE(97308-49-1)

Safety Data

• Hazardous Substances Data: 97308-49-1(Hazardous Substances Data)

Usage

General Description

2-TRIMETHYLSILANYLETHYNYL-3-CYANOPYRIDINE is a chemical compound with the molecular formula C10H12N2Si. It is a member of the pyridine family and contains a triple bond between a carbon and nitrogen atom, as well as a trimethylsilyl group attached to the ethynyl group. 2-TRIMETHYLSILANYLETHYNYL-3-CYANOPYRIDINE is commonly used in organic synthesis and as a reagent in chemical reactions. It is also utilized in the pharmaceutical industry, particularly in the development of new drug compounds. Additionally, its unique structure and properties make it a valuable building block for the preparation of various functional materials and organic molecules.

Upstream product

• 100-54-9 pyridine-3-carbonitrile 
• 133816-00-9 phenyl(trimethylsilylethynyl)iodonium triflate 
• 6602-54-6 2-chloro-3-pyridinecarbonitrile 
• 1066-54-2 trimethylsilylacetylene 

Downstream Products

• 132898-82-9 2-[(E)-2-((R)-1-Phenyl-ethylamino)-vinyl]-nicotinonitrile 
• 132898-88-5 1-Methyl-6-((R)-1-phenyl-ethyl)-4,6,7,8-tetrahydro-1H-[1,6]naphthyridin-5-one 
• 132898-84-1 2-[2-((R)-1-Phenyl-ethylamino)-ethyl]-nicotinonitrile 
• 132898-86-3 6-((R)-1-Phenyl-ethyl)-7,8-dihydro-6H-[1,6]naphthyridin-5-one 
• 23616-31-1 Naphthyridinon 
• 1351516-79-4 6-Amino-1,6-naphthyridin-5(6H)-iminium-2,4,6-trimethylbenzenesulfonate 
• 55570-60-0 1,6-naphthyridin-5-amine 
• 97308-52-6 2-(β,β-dimethoxyethyl)-3-pyridinecarbonitrile 
• 23616-32-2 5-chloro-[1,6]naphthyridine 
• 138850-44-9 1-Methyl-6-<(S)-1-benzylhydroxyethyl>-5-oxo-5,6,7,8-tetrahydro-1,6-naphthyridinium iodide 
• 132898-85-2 2-<2-(N-(S)-1-benzylhydroxyethyl)amino>ethyl-nicotinonitrile 
• 132898-87-4 6-<(S)-1-benzylhydroxyethyl>-5-oxo-5,6,7,8-tetrahydro-1,6-naphthyridine 
• 132898-89-6 1-Methyl-6-<(S)-1-benzylhydroxyethyl>-1,4,5,6,7,8-hexahydro-5-oxo-1,6-naphthyridine 
• 138921-62-7 2-<2-(N-(S)-1-benzylhydroxyethyl)amino>ethenylnicotinonitrile 

Relevant articles and documents

Arylation, Vinylation, and Alkynylation of Electron-Deficient (Hetero)arenes Using Iodonium Salts

Arylation, vinylation, and alkynylation of electron-deficient arenes and heteroarenes have been achieved by chemoselective C-H zincation followed by copper-catalyzed coupling reactions using iodonium salts. This approach offers a direct and general access to a wide scope of (hetero)biaryls as well as alkenylated and alkynylated heteroarenes under mild conditions. It is particularly useful and valuable for the rapid and modular synthesis of diverse (hetero)aryl compounds, as demonstrated in the synthesis of transient receptor potential vanilloid 1 (TRPV1) antagonists and angiotensin II receptor type 1 (AT1 receptor) antagonists.

ANTI-VIRAL COMPOUNDS

Compounds effective in inhibiting replication of Hepatitis C virus ( HCV ) or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, coformulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.

Asymmetric Reductions with Freely and Non-freely Rotating Amide Group NADH Models

NADH models with a freely or a non freely rotating chiral amide group have been synthesized and used in the reduction of methyl benzoylformate.The same major enantiomer was obtained in all cases.A blocked reagent bearing a phenylalaninol group as chiral auxiliary allows one to obtain a high e.e.