23632-78-2

Basic information

• Product Name: Glycine, N-[(1,1-dimethylethoxy)carbonyl]-L-alanyl-, phenylmethyl ester
• Synonyms: Boc-L-Ala-Gly-OBn;((S)-2-tert-Butoxycarbonylamino-propionylamino)-acetic acid benzyl ester;N-t-butoxycarbonyl-L-alanylglycine benzyl ester;Boc-Ala-Gly-OBzl;N-(tert-butoxycarbonyl)-L-alanylglycine benzyl ester
• CAS NO: 23632-78-2
• Molecular Formula: C17H24N2O5
• Molecular Weight: 336.388
• Mol File: 23632-78-2.mol
• Article Data: 16

Chemical Properties

• CAS DataBase Reference: Glycine, N-[(1,1-dimethylethoxy)carbonyl]-L-alanyl-, phenylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Glycine, N-[(1,1-dimethylethoxy)carbonyl]-L-alanyl-, phenylmethyl ester(23632-78-2)
• EPA Substance Registry System: Glycine, N-[(1,1-dimethylethoxy)carbonyl]-L-alanyl-, phenylmethyl ester(23632-78-2)

Safety Data

• Hazardous Substances Data: 23632-78-2(Hazardous Substances Data)

Upstream product

• 1738-76-7 glycine benzyl ester p-toluenesulfonic acid salt 
• 3392-05-0 Boc-Ala-O-N-hydroxysuccinimide 
• 1738-68-7 Gly-OBz 
• 7586-94-9 Boc-Ala-OTcp 
• 15761-38-3 L-N-Boc-Ala 
• 28782-78-7 N-(tert-butyloxycarbonyl)-(S)-alanylglycine 
• 100-51-6 benzyl alcohol 
• 51805-45-9 tris-(2-carboxyethyl)-phosphine hydrochloride 
• 26061-06-3 methyl 2-((2S)-2-((tert-butoxycarbonyl)amino)propanamido)acetate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 2462-31-9 benzyl 2-aminoacetate hydrochloride 

Downstream Products

• 138850-76-7 Boc-Val-Glu(OBzl)-Glu(OBzl)-Lys(Z)-Ala-Gly-OBzl 
• 138850-61-0 Boc-Glu(OBzl)-Glu(OBzl)-Lys(Z)-Ala-Gly-OBzl 
• 138850-60-9 Boc-Glu(OBzl)-Lys(Z)-Ala-Gly-OBzl 
• 138850-59-6 Boc-Lys(Z)-Ala-Gly-OBzl 
• 73870-80-1 Z-Leu-Glu(OBu^t)-Leu-Ala-Gly-OH 
• 73870-78-7 Z-Glu(OBu^t)-Leu-Ala-Gly-OBzl 
• 73870-75-4 Boc-Leu-Ala-Gly-OBzl 
• 73870-76-5 [(S)-2-((S)-2-Amino-4-methyl-pentanoylamino)-propionylamino]-acetic acid benzyl ester 
• 73870-90-3 Boc-Ala-Leu-Glu(OBu^t)-Leu-Ala-Gly-Gly-Pro-Gly-Ala-Gly-Gly-OBzl 
• 187977-13-5 (S)-2-{2-[2-((S)-2-tert-Butoxycarbonylamino-propionylamino)-acetylamino]-acetylamino}-succinic acid 4-benzyl ester 1-(2,2,2-trichloro-ethyl) ester 
• 115035-47-7 (-)-2-(S)-[N-(2-tert-butoxycarbonylaminopropionylamino)acetylamino]acetic acid 
• 73870-83-4 Boc-Ala-Gly-Gly-OBzl 
• 28782-78-7 N-(tert-butyloxycarbonyl)-(S)-alanylglycine 
• 63649-09-2 HCl*Gly-Ala-OBzl 

Relevant articles and documents

Synthesis and Structure-Activity Relationships of Ring-Opened Bengamide Analogues against Methicillin-Resistant Staphylococcus aureus?

Methicillin-resistant Staphylococcus aureus (MRSA) has become a major threat on public health because of the increase of clinically isolated strains that exhibit resistance to many antibiotics. Therefore, development of new antibiotics for the treatment of MRSA infection is a sustained challenge. We have previously identified a ring-opened bengamide analogue L472-2 that displays moderate activity against the growth of S. aureus. In our previous work, we started from L472-2 and identified a class of analogues containing alkynyl groups which have the potential to activate SaClpP activity but moderate antibacterial activity. Herein, we focused on the antibacterial activity of L472-2, and a novel series of ring-opened bengamide analogues were synthesized and their activities were evaluated against MRSA. By conducting a compact analysis of the structure-activity relationships (SAR) of these analogues, we found that an adamantane ethanol ester bengamide 2j showed excellent antibacterial activity towards six S. aureus strains, including MRSA, while it does not activate ClpP. Therefore, these bengamide analogues represent a new class of candidates that suppress MRSA viability.

Glycopeptide derivatives for the preservation and protection of biological materials and microorganisms

The present invention relates to a compound of the following formula (I): in which at least one and only one group chosen among R5, R6 and R7 is a group of the following formula: The present invention relates also to uses

Development of supramolecular organo-gel based on tripeptide skeletons

Boc-Ser-Val-Gly-OCH2Ph (31) showed high gelation abilities in the aromatic solvents, particularly in toluene. The minimum gelation concentration of 31 in toluene was 10 mg/ml, suggesting that 2500 molecules of toluene were immobilized by each m