23672-07-3 Usage
Description
Levosulpiride, also known as (S)-(-)-Sulpiride, is a levorotatory enantiomer of sulpiride, which exhibits greater central antidopaminergic activity, antiemetic, and antidyspeptic effects. It is a selective D2-like dopamine antagonist with high affinity for D2, D3, D4, and D5 receptors. Levosulpiride is a white solid and is used as a therapeutic drug for the treatment of depression and somatoform disorders.
Uses
Used in Pharmaceutical Industry:
Levosulpiride is used as a dopamine receptor antagonist for its antipsychotic, antidepressant, and antiemetic properties. It modulates dopamine D2 and D3-receptor function, which aids in the treatment of various psychiatric and mood disorders.
Used in Research Applications:
Levosulpiride is used as a research tool to study the effect of dopamine D2 receptor function on activation of KCNQ potassium channels and on depression-like behavior in animal models, such as ovariectomized female rats. This helps in understanding the underlying mechanisms of dopamine receptor interactions and their role in various physiological and pathological processes.
Biological Activity
Active enantiomer. Selective D 2 -like dopamine antagonist (K i values are ~ 0.015. ~ 0.013, 1, ~ 45 and ~ 77 μ M at D 2 , D 3 , D 4 , D 1 and D 5 receptors respectively).
Biochem/physiol Actions
(S)-(?)-Sulpiride or Levosulpiride blocks the inhibitory enteric D2 receptors (neuronal and muscular). It has prokinetic activity and is effective in the treatment of functional dyspepsia and gastroparesis in insulin-dependent diabetes mellitus patients.7,8 Since dopamine controls human sexual function, (S)-(?)-Sulpiride is reportedly effective in treatment of erectile dysfunctions.9
Check Digit Verification of cas no
The CAS Registry Mumber 23672-07-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,3,6,7 and 2 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 23672-07:
(7*2)+(6*3)+(5*6)+(4*7)+(3*2)+(2*0)+(1*7)=103
103 % 10 = 3
So 23672-07-3 is a valid CAS Registry Number.
InChI:InChI=1/C15H23N3O4S/c1-3-18-8-4-5-11(18)10-17-15(19)13-9-12(23(16,20)21)6-7-14(13)22-2/h6-7,9,11H,3-5,8,10H2,1-2H3,(H,17,19)(H2,16,20,21)/t11-/m0/s1
23672-07-3Relevant articles and documents
A postoperative or its optical isomers of synthetic and post-processing method
-
Paragraph 0024; 0025, (2018/09/11)
The invention relates to a synthesis and post-processing method of sulpiride or an optical isomer thereof, and the synthesis and post-processing method include the following steps: under inert gas protection, heating 2-methoxy-5-aminosulfonyl methyl benzoate or 2-methoxy-5-aminosulfonyl ethyl benzoate and 1-ethyl-2-aminomethyl pyrrolidine or an optical isomer thereof at 80-120 DEG C for a plurality of hours, and after the reaction is completed, adding ethanol for processing, cooling, filtering, washing and drying.
Synthesis and Inhibitory Activity on Carbonic Anhydrase of Some New Sulpiride Analogues Studied by Means of a New Method
Botre, Claudio,Botre, Francesco,Jommi, Giancarlo,Signorini, Roberto
, p. 1814 - 1820 (2007/10/02)
The pharmacological activity of several new sulpiride analogues was studied by means of a new approach, based on a potentiometric technique with a pCO2 sensor, capable of detecting carbonic anhydrase inhibition at equilibrium conditions.This procedure gives results stated as percent of inhibition of enzymatic activity (IP, inhibitory power).To prove the reliability of the proposed approach and to study structure-activity relationships, several new molecules were synthesized and tested in comparison with the two sulpiride enantiomers.A possible inhibition mechanism is discussed in terms of experimental evidence obtained from the interactions between the molecular structures of the new synthesized compounds and carbonic anhydrase.