2386-27-8Relevant articles and documents
Steric control of mesocate and helicate formation: Bulky pyrrol-2-yl Schiff base complexes of Zn2+
Gorden, A. E. V.,Gorden, J. D.,Hiti, E. A.,Mayhugh, J. T.,Niklas, J. E.,Wilkinson, G. R.
supporting information, (2022/01/14)
Regioisomerism about a phenyl spacer alters the number of nuclei which participate in self-assembly with pyrrole/schiff base ditopic ligands. The bulky benzyl ester substituents favor formation of di- and tetranuclear (but not trinuclear) complexes. The r
Total synthesis of hematoporphyrin and protoporphyrin; A conceptually new approach
Martin, Pierre,Mueller, Markus,Flubacher, Dietmar,Boudier, Andreas,Spielvogel, Dirk
, p. 204 - 206 (2013/07/05)
The total synthesis of protoporphyrin IX and its disodium salt using a new alternative method to the classical MacDonald condensation is reported. The key step is the reaction of the new unsymmetrical diiodo dipyrrylmethane 1 with the known dipyrrylmethane 2. Coupling of the two fragments leads directly to porphyrin 3 without the need of an oxidizing agent. The new methodology is well suited for the synthesis of protoporphyrin IX derivatives on a multi-100 g scale in good quality without the need for chromatography. Furthermore, these preparations are completely free of any contaminant of animal origin, which represents a real improvement in the manufacturing of protoporphyrin IX derivatives. Schweizerische Chemische Gesellschaft.
Process For Preparing Porphyrin Derivatives, Such As Protoporphyrin (IX) And Synthesis Intermediates
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Page/Page column 12; 16, (2008/12/07)
The present invention relates to a process for preparing a porphyrin of formula (I), optionally in the form of a salt with an alkali metal and/or in the form of a metal complex: in which: R and R′ are as defined in claim 1, comprising: a step of condensation, in an acidic medium, between a dipyrromethane of formula (II): in which R′b is as defined above for (I), and a dipyrromethane of formula (III): in which R″ is as defined in claim 1, and also the compounds of formula (III).