23972-41-0

Basic information

• Product Name: 2-PHENYLMORPHOLINE
• Synonyms: 2-phenylmorpholine(SALTDATA: FREE);Morpholine, 2-phenyl-;2-PHENYL MORPHOLINE HCL;2FMA-0-1
• CAS NO: 23972-41-0
• Molecular Formula: C₁₀H₁₃NO
• Molecular Weight: 163.2163
• Product Categories: pharmacetical
• Mol File: 23972-41-0.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 278.6°Cat760mmHg
• Flash Point: 107.3°C
• Appearance: /
• Density: 1.034g/cm³
• Vapor Pressure: 0.00423mmHg at 25°C
• Refractive Index: 1.518
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 8.52±0.40(Predicted)
• CAS DataBase Reference: 2-PHENYLMORPHOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-PHENYLMORPHOLINE(23972-41-0)
• EPA Substance Registry System: 2-PHENYLMORPHOLINE(23972-41-0)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 23972-41-0(Hazardous Substances Data)

Usage

General Description

2-Phenylmorpholine is a type of chemical compound belonging to the class of organic compounds known as phenylmorpholines, which are aromatic compounds containing a morpholine ring substituted by a phenyl group. 2-PHENYLMORPHOLINE can exist in different forms called isomers, but the most stable form is a liquid. It's used in a variety of areas, including in the production of certain types of polymers and as an intermediate in organic synthesis. Known hazards related to this chemical include skin and eye irritation, harmful if swallowed or inhaled, and may cause an allergic skin reaction. Its toxicological properties have not been investigated fully.

InChI:InChI=1/C10H13NO/c1-2-4-9(5-3-1)10-8-11-6-7-12-10/h1-5,10-11H,6-8H2

Upstream product

• 23980-75-8 4-benzyl-2-phenyl-morpholine 
• 108-86-1 bromobenzene 
• 23980-35-0 [2-bromo-1-(2-chloro-ethoxy)-ethyl]-benzene 
• 74572-09-1 N-(2-hydroxyethyl)-N-(2-hydroxy-2-phenylethyl)amine 
• 321977-41-7 2-phenyl-4-(toluene-4-sulfonyl)morpholine 
• 953986-10-2 4-((4-nitrophenyl)sulfonyl)-2-phenylmorpholine 
• 100-42-5 styrene 

Downstream Products

• 1134191-13-1 4-[2-(2-phenylmorpholin-4-yl)propyl]phenol 
• 1219624-65-3 1-[2-oxo-2-(2-phenylmorpholin-4-yl)ethyl]-3,3-diphenylpiperidin-2-one 
• 1145786-03-3 4-{6-[4-(4-methyl-1H-imidazol-1-yl)-3-(methyloxy)phenyl]-3-pyridazinyl}-2-phenylmorpholine 
• 152134-83-3 4-Amino-N-[1-(1H-benzimidazol-5-yl-methyl)-2-(2-phenylmorpholin-4-yl)-2-oxo-ethyl]-3,5-dichlorobenzenesulphonamide 

Relevant articles and documents

Catalyst-free and metal-free electrophilic bromoamidation of unactivated olefins using the N-bromosuccinimide/sulfonamide Protocol

An efficient, catalyst-free, and metal-free bromoamidation of unactivated olefins has been developed. 4-(Trifluoromethyl)benzenesulfonamide and N-bromosuccinimide were used as the nitrogen and halogen sources, respectively. The methodology is applicable to both cyclic and aliphatic olefins.

Substituted 1,2,3,4-tetrahydroquinolin-6-yloxypropanes as β3-adrenergic receptor agonists: Design, synthesis, biological evaluation and pharmacophore modeling

In search of potent β3-adrenergic receptor agonists, a series of novel substituted 1,2,3,4-tetrahydroquinolin-6-yloxypropanes has been synthesized and evaluated for their β3-adrenergic receptor agonistic activity (ranging from -17.73% to 90.64% inhibition at 10 μM) using well established Human SK-N-MC neuroblastoma cells model. Four molecules viz. 11, 15, 22 and 23 showed β3-AR agonistic IC50 value of 0.55, 0.59, 1.18 and 1.76 μM, respectively. These four candidates have been identified as possible leads for further development of β3-adrenergic receptor agonists for obesity and Type-II diabetes pharmacotherapy. The free OH and NH functions are found to be essential for β3-adrenergic receptor agonistic activity. Among the synthesized β3-adrenergic receptor agonists having 1,2,3,4-tetrahydroquinoline scaffold, the N-benzyl group is found to be superior over N-arylsulfonyl group. A putative pharmacophore model has been modeled considering the above four active molecules which distinguishes well between the active and inactive molecules.