24043-97-8

Basic information

• Product Name: ETHYL 2-(2-THIENYL)-1,3-THIAZOLE-4-CARBOXYLATE
• Synonyms: ETHYL 2-(2-THIENYL)-1,3-THIAZOLE-4-CARBOXYLATE;ETHYL 2-(THIEN-2-YL)THIAZOLE-4-CARBOXYLATE;ethyl 2-(thiophen-2-yl)thiazole-4-carboxylate;Ethyl 2-(2-thienyl)thiazole-4-carboxylate, 97%;4-Thiazolecarboxylic acid, 2-(2-thienyl)-, ethyl ester;ethyl 2-thiophen-2-yl-1,3-thiazole-4-carboxylate;Ethyl 2-(thiophen-2-yl)
• CAS NO: 24043-97-8
• Molecular Formula: C10H9NO2S2
• Molecular Weight: 239.31
• Mol File: 24043-97-8.mol
• Article Data: 7

Chemical Properties

• Melting Point: 85-87°C
• Boiling Point: 374.7 °C at 760 mmHg
• Flash Point: 180.4 °C
• Appearance: /
• Density: 1.319 g/cm³
• Vapor Pressure: 8.19E-06mmHg at 25°C
• Refractive Index: 1.601
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: -0.02±0.10(Predicted)
• CAS DataBase Reference: ETHYL 2-(2-THIENYL)-1,3-THIAZOLE-4-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 2-(2-THIENYL)-1,3-THIAZOLE-4-CARBOXYLATE(24043-97-8)
• EPA Substance Registry System: ETHYL 2-(2-THIENYL)-1,3-THIAZOLE-4-CARBOXYLATE(24043-97-8)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 24043-97-8(Hazardous Substances Data)

Usage

General Description

Ethyl 2-(2-thienyl)-1,3-thiazole-4-carboxylate is a chemical compound with the molecular formula C10H9NO2S2. Distinguished for its unique structural configuration that aligns it with the thiazole and thiophene group of organic compounds - both of which are heterocyclic compounds due to the presence of more than one type of atom in their ring structure. Precise details regarding its physical properties or chemical reactivity are not readily available due to its unique and complex structure. Despite a lack of comprehensive data, such compounds are commonly involved in medical, agricultural, and industrial research due to their general versatility and potential applicability.

InChI:InChI=1/C10H9NO2S2/c1-2-13-10(12)7-6-15-9(11-7)8-4-3-5-14-8/h3-6H,2H2,1H3

Upstream product

• 24044-03-9 2-thiophen-2-yl-thiazole-4,5-dicarboxylic acid 4-ethyl ester 
• 20300-02-1 thiophene-2-carbothioamide 
• 673476-96-5 (2-chloro-phenyl)-thioacetic acid amide 
• 98-03-3 thiophene-2-carbaldehyde 
• 868-59-7 L-cysteine ethyl ester hydrochloride 
• 617-35-6 2-oxo-propionic acid ethyl ester 
• 70-23-5 ethyl Bromopyruvate 
• 5813-89-8 2-thiophenylcarboxamide 
• 34034-87-2 diethyl 3-chloro-2-oxosuccinate 
• 14037-19-5 2-thiophen-2-yl-thiazole-4,5-dicarboxylic acid diethyl ester 

Downstream Products

• 154323-99-6 2-(2-thienyl)-4-thiazolecarbohydrazide 
• 54986-94-6 (2-thiophen-2-ylthiazole-4-yl)methanol 
• 306934-98-5 2-(2-thienyl)-4-thiazolecarboxylic acid chloride 
• 24044-07-3 2-thiophen-2-yl-thiazole-4-carboxylic acid 

Relevant articles and documents

I2/TBHP-Mediated tandem cyclization and oxidation reaction: Facile access to 2-substituted thiazoles and benzothiazoles

The efficient synthesis of 2-substituted thiazoles and benzothiazoles has been accomplished employing readily available cysteine esters and 2-aminobenzenethiols as N and S sources. The reaction proceeds under an I2/TBHP system and involves a on

Solvent-free synthesis of bacillamide analogues as novel cytotoxic and anti-inflammatory agents

Synthesis of fourteen analogues of bacillamide, a bioactive tryptamide alkaloid of marine origin, has been accomplished through a highly efficient convergent route. The present solvent-free protocol involves the formation of thiazole ring in the initial step followed by amide coupling between substituted ethyl 2-alkyl/aryl/heteroaryl/amino/aminoarylthiazole-4-carboxylates and tryptamine in presence of 2-hydroxy-4,6-dimethylpyrimidine, a solid phase catalyst to yield N-[2-(1H-indol-3-yl)ethyl]-2-alkyl/aryl/heteroaryl/amino/aminoarylthiazole-4-carboxamides as bacillamide analogues having structural variation at position-2 of thiazole ring. Bacillamide and its analogues were evaluated for their cytotoxic activity against three cancer cell lines (HCT-116, MDA-MD-231 and JURKAT cell lines) using colorimetric cell proliferation assay. Compounds 17a and 17b exhibited potent anti-cell proliferation activity with IC50values in the range of ～3.0?μM and ～0.1–0.6?μM, respectively against these cell lines. Preliminary mechanism of action studies indicates that these compounds initiate caspase dependent apoptosis. Also, compounds 16d, 16f, 17a and 17d exhibited excellent anti-inflammatory activity comparable to well-known NSAID indomethacin and better to bacillamide, when evaluated using carrageenan induced rat hind paw oedema method.

THIAZOLE COMPOUNDS, METHODS FOR PREPARATION AND USE THEREOF

The present invention relates to thiazole compounds of formula I, the method for preparation and use thereof. More specifically, the present invention relates to novel derivatives of natural product largazole, the method for preparing them and their uses