34034-87-2Relevant articles and documents
Dual Photoredox/Cobaloxime Catalysis for Cross-Dehydrogenative α-Heteroarylation of Amines
Bergamaschi, Enrico,Weike, Christopher,Mayerhofer, Victor J.,Funes-Ardoiz, Ignacio,Teskey, Christopher J.
supporting information, p. 5378 - 5382 (2021/07/26)
We report a dual-catalytic platform for the cross-dehydrogenative-coupling between (benzo-)thiazoles and amines which combines low loadings of an iridium photoredox catalyst and a cobaloxime catalyst under blue light irradiation. This transformation occurs without stoichiometric oxidants, giving products in moderate to excellent yields. DFT calculations support the key role of Co(II) for rearomatization of the radical-addition intermediate to generate the product.
A 4 - (1 - hydroxy -1 - methyl ethyl) -2 - propyl - 1H - imidazole -5 - carboxylic acid ethyl ester preparation method
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Paragraph 0033; 0039; 0040; 0041, (2017/08/25)
The invention relates to a preparation method of 4-(1-hydroxy-1-methyl ethyl)-2-propyl-1H-imidazole-5-carboxylic acid ethyl ester and belongs to the technical field of medicament synthesis. In order to solve the problems of long reaction route, heavy pollution and low yield in the prior art, the invention provides a preparation method of 4-(1-hydroxy-1-methyl ethyl)-2-propyl-1H-imidazole-5-carboxylic acid ethyl ester. The method comprises the following steps: in the presence of organic alkali, enabling a raw material alpha-chlorinated oxaloacetic acid diethyl ester to react with butanimidamide or acidic salt of butanimidamide to obtain an intermediate compound, then enabling the intermediate compound to perform Grignard reaction with CH3MgX to obtain 4-(1-hydroxy-1-methyl ethyl)-2-propyl-1H-imidazole-5-carboxylic acid ethyl ester, wherein X in CH3MgX is halogen. The method disclosed by the invention has the advantages of short reaction route, less pollution, mild reaction condition and high yield.
Simple method for the preparation of dialkyl (2,3-dihydro-1,3-thiazol-2-YL) -phosphonates
Janikowska, Karolina,Makowiec, Slawomir
experimental part, p. 12 - 20 (2011/03/20)
A simple synthesis of dialkyl (2,3-dihydro-1,3-thiazol-2-yl)-phosphonates from thiazolium salts and trialkyl phosphites is described. The series of dialkyl (2,3-dihydro-1,3-thiazol-2-yl)-phosphonates with various substituents in positions 3, 4, and 5 of the thiazole ring were prepared. However, only phosphonates with an aryl on the nitrogen atom were stable enough for chromatographic purification, although all the new phosphonates are very sensitive to oxidation. We made efforts to apply dialkyl (2,3-dihydro-1,3- thiazol-2-yl)-phosphonates in a Horner-Wadsworth-Emmons reaction, but the generated antiaromatic anion of phosphonate decomposed quickly, even at -70°C. Copyright Taylor & Francis Group, LLC.