24122-26-7

Basic information

• Product Name: 3-(3-chlorophenyl)quinazolin-4(3H)-one
• Synonyms: 3-(3-Chloro-phenyl)-3H-quinazolin-4-one
• CAS NO: 24122-26-7
• Molecular Formula: C₁₄H₉ClN₂O
• Molecular Weight: 256.6871
• Mol File: 24122-26-7.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 435.8°C at 760 mmHg
• Flash Point: 217.4°C
• Density: 1.31g/cm³
• Vapor Pressure: 8.48E-08mmHg at 25°C
• Refractive Index: 1.66
• CAS DataBase Reference: 3-(3-chlorophenyl)quinazolin-4(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(3-chlorophenyl)quinazolin-4(3H)-one(24122-26-7)
• EPA Substance Registry System: 3-(3-chlorophenyl)quinazolin-4(3H)-one(24122-26-7)

Safety Data

• Hazardous Substances Data: 24122-26-7(Hazardous Substances Data)

Upstream product

• 119072-55-8 tert-butylisonitrile 
• 22312-61-4 2-amino-N-(3-chlorophenyl)benzamide 
• 107-21-1 ethylene glycol 
• 75-91-2 tert.-butylhydroperoxide 
• 121-73-3 3-Nitrochlorobenzene 
• 10113-38-9 N-(2-bromophenyl)formamide 
• 13939-06-5 molybdenum hexacarbonyl 
• 118-92-3 anthranilic acid 
• 108-42-9 3-chloro-aniline 
• 149-73-5 trimethyl orthoformate 
• 122-51-0 orthoformic acid triethyl ester 

Downstream Products

• 340-94-3 2-methyl-3-(m-chlorophenyl)-4(3H)-quinazolinone 

Relevant articles and documents

Transition-metal and oxidant-free approach for the synthesis of diverse N-heterocycles by TMSCl activation of isocyanides

A highly efficient TMSCl-mediated addition of N-nucleophiles to isocyanides has been achieved. This transition-metal and oxidant-free strategy has been applied to the construction of various N-heterocyles such as quinazolinone, benzimidazole and benzothiazole derivatives by the use of distinct amino-based binucleophiles. The notable feature of this protocol includes its mild reaction condition, broad functional group tolerance and excellent yield. This journal is

Screening of natural deep eutectic solvents for green synthesis of 2-methyl-3-substituted quinazolinones and microwave-assisted synthesis of 3-aryl quinazolinones in ethanol

In this study, two fast and efficient protocols for green synthesis of 3-substituted quinazolinones were perfomed. A synthesis of 2-methyl-3-substituted quinazolinones was performed in natural deep eutectic solvents, while 3-aryl quinazolinones were obtained by using microwave assisted synthesis. Benzoxazinone, which was used as an intermediate in the synthesis of 2-methyl-3-substituted quinazolinones, was prepared conventionally from anthranilic acid and acetic anhydride. In order to find the most appropriate synthetic path, twenty natural deep eutectic solvents were applied as a solvent in these syntheses. Choline chloride:urea (1: 2) was found to be the most efficient solvent and was further used in the synthesis of 2-methyl quinazolinone derivatives (2–12). 3-Aryl quinazolinones (13–17), on the other hand, were synthesized in one-pot microwave-assisted reaction of anthranilic acid, different amines and trimethyl orthoformate. All compounds were synthesized in good to excellent yields, characterized by LC-MS/MS spectrometry and 1H- and 13C-NMR spectroscopy.

A convenient palladium-catalyzed carbonylative synthesis of 4(3H)-quinazolinones from 2-bromoformanilides and organo nitros with Mo(CO) 6 as a multiple promoter

A novel and convenient procedure for the synthesis of quinazolinones has been developed. Using 2-bromoformanilides and organo nitros as substrates and Mo(CO)6 as a multiple promoter, the desired products were isolated in moderate to excellent yields in the presence of a palladium catalyst. Here, Mo(CO)6 was not only a CO source, but also a nitro compound reducing reagent and a cyclization promoter. This journal is the Partner Organisations 2014.