340-94-3

Basic information

• Product Name: 3-(3-chlorophenyl)-2-methyl-4(3H)-quinazolinone
• Synonyms: 3-(3-chlorophenyl)-2-methyl-4(3H)-quinazolinone
• CAS NO: 340-94-3
• Molecular Formula: C₁₅H₁₁ClN₂O
• Molecular Weight: 270.71364
• Mol File: 340-94-3.mol
• Article Data: 9

Chemical Properties

• Melting Point: 130 °C
• Boiling Point: 439.1°C at 760 mmHg
• Flash Point: 219.4°C
• Appearance: /
• Density: 1.29g/cm³
• Vapor Pressure: 6.54E-08mmHg at 25°C
• Refractive Index: 1.647
• PKA: 2.02±0.70(Predicted)
• CAS DataBase Reference: 3-(3-chlorophenyl)-2-methyl-4(3H)-quinazolinone(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(3-chlorophenyl)-2-methyl-4(3H)-quinazolinone(340-94-3)
• EPA Substance Registry System: 3-(3-chlorophenyl)-2-methyl-4(3H)-quinazolinone(340-94-3)

Safety Data

• Hazardous Substances Data: 340-94-3(Hazardous Substances Data)

Usage

InChI:InChI=1/C15H11ClN2O/c1-10-17-14-8-3-2-7-13(14)15(19)18(10)12-6-4-5-11(16)9-12/h2-9H,1H3

Upstream product

• 525-76-8 2-methyl-4-oxo-3,1-benzoxazine 
• 108-42-9 3-chloro-aniline 
• 118-92-3 anthranilic acid 
• 22312-61-4 2-amino-N-(3-chlorophenyl)benzamide 
• 123-54-6 acetylacetone 
• 141-85-5 3-chloroaniline hydrochloride 
• 25116-00-1 2-acetamidobenzonitrile 
• 89-52-1 o-acetylamino-benzoic acid 
• 24122-26-7 3-(3-chlorophenyl)quinazolin-4(3H)-one 

Downstream Products

• 123382-21-8 3-(3-Chloro-phenyl)-2-(2-oxo-2-pyridin-4-yl-ethyl)-3H-quinazolin-4-one 

Relevant articles and documents

Metal-free C-H methylation and acetylation of heteroarenes with PEG-400

The generation of a methyl carbon source from renewable and cheap sources is challenging. Herein, we describe a novel and an efficient route for methylation and acetylation of aza-heteroarenes using PEG-400 under O2and TsOH·H2O for the first time by tuning the reaction conditions using a different set of starting materials. The key features of the current protocol are oxidative C-O and C-C bond scission under metal-free conditions with good functional group tolerance, and a broad substrate scope. The potential applicability of the designed methodology was demonstrated for the synthesis of central nervous system (CNS) depressant and anticonvulsant drug molecules by a one-pot strategy.

A quinazoline compound and its synthesis method

The invention discloses a synthetic method of a quinazolinone compound. The method can be used for preparing the quinazolinone compound by carrying out reaction at a proper temperature and time by taking a 2-aminobenzamide derivative and a 1, 3-diketone compound as raw materials, taking chiral Bronsted acid or Lewis acid as a catalyst and water and biodegradable ethyl lactate and polyethylene glycol as a mixed solvent. The synthetic method of the quinazolinone compound provided by the invention is mild in reaction condition, low in cost, environment-friendly, high in yield and suitable for industrial production.

FeCl3-catalyzed tandem condensation/intramolecular nucleophilic addition/C-C bond cleavage: A concise synthesis of 2-substitued quinazolinones from 2-aminobenzamides and 1,3-diketones in aqueous media

A concise approach for the synthesis of 2-substituted quinazolinones using an iron-catalyzed tandem reaction of 2-aminobenzamides with acyclic or cyclic 1,3-diketones via condensation, intramolecular nucleophilic addition, C-C bond cleavage in an aqueous solution of poly(ethylene glycol) under oxidant-free conditions has been developed.