24168-42-1

Basic information

• Product Name: alpha-methylnaphthalene-1-acetonitrile
• Synonyms: alpha-methylnaphthalene-1-acetonitrile;α-Methyl-1-naphthaleneacetonitrile;Einecs 246-049-3
• CAS NO: 24168-42-1
• Molecular Formula: C₁₃H₁₁N
• Molecular Weight: 181.23314
• EINECS: 246-049-3
• Mol File: 24168-42-1.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 333.1°Cat760mmHg
• Flash Point: 172.7°C
• Appearance: /
• Density: 1.085g/cm³
• CAS DataBase Reference: alpha-methylnaphthalene-1-acetonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: alpha-methylnaphthalene-1-acetonitrile(24168-42-1)
• EPA Substance Registry System: alpha-methylnaphthalene-1-acetonitrile(24168-42-1)

Safety Data

• Hazardous Substances Data: 24168-42-1(Hazardous Substances Data)

Upstream product

• 91-20-3 naphthalene 
• 107-13-1 acrylonitrile 
• 1127-76-0 1-ethylnapthelene 
• 151-50-8 potassium cyanide 
• 13234-68-9 3-cyano-3-[1]naphthyl-propionic acid 
• 74-88-4 methyl iodide 
• 86-53-3 1-Cyanonaphthalene 
• 6839-20-9 2-[(methylsulfonyl)oxy]propanenitrile 
• 90-13-1 1-Chloronaphthalene 
• 941-98-0 1'-naphthacetophenone 
• 38622-91-2 [(p-methylphenyl)sulfonylmethyl]isonitrile 
• 132-75-2 naphthalen-1-ylacetonitrile 
• 137967-92-1 methyl 3-cyano-3-(naphth-1-yl) propionate 
• 7677-24-9 trimethylsilyl cyanide 

Downstream Products

• 27557-86-4 2-(naphth-1-yl)propanamine 
• 54835-36-8 2-Naphthalen-1-yl-2-phenylsulfanyl-propionitrile 
• 941-98-0 1'-naphthacetophenone 
• 3900-63-8 (+/-)-3,4,5-Trimethoxy-benzoesaeure-<2-<1>naphthyl-propylamid> 
• 1127-76-0 1-ethylnapthelene 
• 134895-45-7 2-(1-naphthyl)propionaldehyde 

Relevant articles and documents

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Asymmetric Deoxygenative Cyanation of Benzyl Alcohols Enabled by Synergistic Photoredox and Copper Catalysis?

Summary of main observation and conclusion. An enantioselective deoxygenative cyanation of benzyl alcohols was accomplished for the first time through the synergistic photoredox and copper catalysis. This reaction features the use of organic photosensitizer and low-cost 3d metal catalyst, simple and safe operations, and extremely mild conditions. A variety of chiral benzyl nitriles were produced in generally good yields and high level of enantiocontrols from readily available feedstocks (22 examples, up to 93% yield and 92% ee).

Nickel-Catalyzed Cyanation of Benzylic and Allylic Pivalate Esters

A nickel-catalyzed cyanation reaction of benzylic and allylic pivalate esters is reported using an air-stable Ni(II) precatalyst and substoichiometric quantities of Zn(CN)2. Alkene additives were found to inhibit catalysis, suggesting that avoiding β-hydride elimination side reactions is essential for productive catalysis. An enantioenriched allylic ester undergoes enantiospecific cross-coupling to produce an enantioenriched allylic nitrile. This method was applied to an efficient synthesis of (±)-naproxen from commercially available starting materials.