2420-16-8

Basic information

• Product Name: 3-Chloro-4-hydroxybenzaldehyde
• Synonyms: Benzaldehyde, 3-chloro-4-hydroxy-;TIMTEC-BB SBB004014;TIMTEC-BB SBB005887;AKOS B028967;3-CHLORO-4-HYDROXYBENZALDEHYDE;3-CHLORO-4-HYROXYBENZALDEHYDE;3-Chloro-4-hydroxybenzaldehyde 98%;3-Chloro-4-hydroxybenzaldehyde, 99+%
• CAS NO: 2420-16-8
• Molecular Formula: C₇H₅ClO₂
• Molecular Weight: 156.57
• Product Categories: Aromatic Aldehydes & Derivatives (substituted);Aldehydes;Phenyls & Phenyl-Het;Benzaldehyde;Phenyls & Phenyl-Het;C7;Carbonyl Compounds
• Mol File: 2420-16-8.mol
• Article Data: 25

Chemical Properties

• Melting Point: 145-147 °C(lit.)
• Boiling Point: 150 °C / 14mmHg
• Flash Point: 105.634 °C
• Appearance: white to pink solid, powder or crystals
• Density: 1.2683 (rough estimate)
• Vapor Pressure: 0.00363mmHg at 25°C
• Refractive Index: 1.5812 (estimate)
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 6.30±0.18(Predicted)
• Sensitive: Air Sensitive
• CAS DataBase Reference: 3-Chloro-4-hydroxybenzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Chloro-4-hydroxybenzaldehyde(2420-16-8)
• EPA Substance Registry System: 3-Chloro-4-hydroxybenzaldehyde(2420-16-8)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 36/37/38-43-41-37/38-22-20/21/22
• Safety Statements: 26-37/39-36/37/39-36-37
• WGK Germany: 3
• Hazardous Substances Data: 2420-16-8(Hazardous Substances Data)

Usage

Chemical Properties

White solid

InChI:InChI=1/C7H5ClO2/c8-7-3-6(10)2-1-5(7)4-9/h1-4,10H

Upstream product

• 50-00-0 formaldehyd 
• 95-57-8 2-monochlorophenol 
• 302-17-0 chloral hydrate 
• 67-66-3 chloroform 
• 68243-92-5 2,2,2-trichloro-1-(3-chloro-4-hydroxy-phenyl)-ethanol 
• 141805-79-0 3-Chlor-4-hydroxybenzylchlorid 
• 105960-29-0 2-chloro-4-(hydroxymethyl)phenol 
• 507-40-4 tert-butylhypochlorite 
• 123-08-0 4-hydroxy-benzaldehyde 
• 76-03-9 trichloroacetic acid 
• 127-68-4 sodium 3-nitrobenzenesulfonate 
• 3964-57-6 methyl 4-hydroxy-3-chlorobenzoate 
• 100-39-0 benzyl bromide 
• 6640-27-3 2-chloro-p-cresol 

Downstream Products

• 66422-84-2 4-benzyloxy-3-chlorobenzaldehyde 
• 102657-71-6 3-chloro-4-(dodecyloxy)benzaldehyde 
• 851373-30-3 2-chloro-4-(chlorocarbonyl)phenyl-4-dodecyloxybenzoate 
• 81490-64-4 3-chloro-4-hydroxy-5-[(4-hydroxypiperidin-1-yl)methyl]benzaldehyde 
• 148580-06-7 (2S,3S,4S,5R,6S)-3,4,5-Triacetoxy-6-(2-chloro-4-formyl-phenoxy)-tetrahydro-pyran-2-carboxylic acid methyl ester 
• 124956-02-1 3-Chloro-4-[(2-methoxyethoxy)methoxy]benzaldehyde 
• 16231-54-2 ethyl [2-chloro-4-formylphenoxy]acetate 
• 1849-76-9 3-bromo-5-chloro-4-hydroxybenzaldehyde 
• 124652-13-7 (2R,4S)-2-(3-Chloro-4-hydroxy-phenyl)-5,5-dimethyl-thiazolidine-4-carboxylic acid 
• 124652-13-7 (2S,4S)-2-(3-Chloro-4-hydroxy-phenyl)-5,5-dimethyl-thiazolidine-4-carboxylic acid 
• 124685-93-4 (2S,4S)-2-(4-Acetoxy-3-chloro-phenyl)-3-acetyl-5,5-dimethyl-thiazolidine-4-carboxylic acid 
• 52507-43-4 3-chloro-4-hydroxycinnamic acid 
• 107149-89-3 N,N'-(3-chloro-4-hydroxy-benzylidene)-bis-propionamide 
• 105960-29-0 2-chloro-4-(hydroxymethyl)phenol 

Relevant articles and documents

Preparation method of 3-methoxy-4-hydroxybenzaldehyde

The invention discloses a preparation method of 3-methoxy-4-hydroxybenzaldehyde, which belongs to the technical field of biochemical technology materials. The method comprises the following specific steps of adding o-chlorophenol, anhydrous aluminum chloride and toluene into a three-neck flask, stirring for dissolving, heating for reflux, then adding diethylamine, continuously refluxing, adding formic anhydride lithium salt, adjusting the PH value, carrying out suction filtration, carrying out reduced pressure distillation, and collecting fractions to obtain 3-chloro-4-hydroxybenzaldehyde, and adding the obtained 3-chloro-4-hydroxybenzaldehyde, anhydrous magnesium chloride and benzene into a three-neck flask, mixing, dissolving, heating, refluxing, dropwise adding a 10% sodium hydroxide solution, uniformly adding sodium methoxide in three batches, cooling to room temperature, adjusting the PH value, carrying out suction filtration, and carrying out reduced pressure distillation to finally obtain the 3-methoxy-4-hydroxybenzaldehyde product. Compared with a traditional method, the synthetic route is not long, the reaction condition is mild, and the yield is high.

Towards the total synthesis of chondrochloren A: Synthesis of the (Z)-enamide fragment

The stereoselective synthesis of the (Z)-enamide fragment of chondrochloren (1) is described. A Buchwald-type coupling between amide 3 and (Z)-bromide 4 was used to generate the required fragment. The employed amide 3 comprising three chiral centers was o

Rate enhancements due to ultrasound in isoquinolinium dichromate and isoquinolinium chlorochromate catalyzed chlorination of aromatic compounds in presence of KHSO4/KCl

Chlorination of aromatic compounds underwent magnificent rate accelerations in isoquinolinium dichromate and isoquinolinium chlorochromate catalyzed chlorination of aromatic hydrocarbons in the presence of KCl and KHSO4. Reaction times reduced highly significantly from 4-5 h in conventional protocol to 30-40 min under sonication, followed by high yields of monochloro derivatives as products with high regioselectivity.