242139-33-9

Basic information

• Product Name: N-(2-chloro-4-nitrophenyl)-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide
• CAS NO: 242139-33-9
• Molecular Weight: 312.633
• Mol File: 242139-33-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-(2-chloro-4-nitrophenyl)-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-chloro-4-nitrophenyl)-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide(242139-33-9)
• EPA Substance Registry System: N-(2-chloro-4-nitrophenyl)-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide(242139-33-9)

Safety Data

• Hazardous Substances Data: 242139-33-9(Hazardous Substances Data)

Upstream product

• 121-87-9 2-Chloro-4-nitroaniline 
• 243869-56-9 R/S-3,3,3-trifluoro-2-hydroxy-2-methylproanoyl chloride 
• 114645-34-0 (R,S)-3,3,3-trifluoro-2-hydroxy-2-methylpropionamide 

Downstream Products

• 1150248-65-9 C₁₀H₁₀ClF₃N₂O₂ 

Relevant articles and documents

Liver X receptor agonists with selectivity for LXRβ; N-aryl-3,3,3-trifluoro-2-hydroxy-2-methylpropionamides

The synthesis and SAR of a new series of LXR agonist is reported. The N-Aryl-3,3,3-trifluoro-2-hydroxy-2-methyl-propionamide hits were found in a limited screen of the AstraZeneca compound collection. The effort to optimize these hits into LXRβ selectivity is described. Compound 20 displayed desirable pharmacokinetic profile and up regulation of ABCA1 and ABCG1 mRNA in the brain were achieved when evaluated in vivo in mice.