114645-34-0

Basic information

• Product Name: PropanaMide, 3,3,3-trifluoro-2-hydroxy-2-Methyl-, (±)-
• Synonyms: PropanaMide, 3,3,3-trifluoro-2-hydroxy-2-Methyl-, (±)-;2-(trifluoromethyl)-2-hydroxypropanamide
• CAS NO: 114645-34-0
• Molecular Formula: C₄H₆F₃NO₂
• Molecular Weight: 157.0911496
• EINECS: -0
• Mol File: 114645-34-0.mol
• Article Data: 3

Chemical Properties

• Melting Point: 142 °C
• Boiling Point: 267.0±40.0 °C(Predicted)
• Appearance: /
• Density: 1.437±0.06 g/cm3(Predicted)
• PKA: 10.63±0.29(Predicted)
• CAS DataBase Reference: PropanaMide, 3,3,3-trifluoro-2-hydroxy-2-Methyl-, (±)-(CAS DataBase Reference)
• NIST Chemistry Reference: PropanaMide, 3,3,3-trifluoro-2-hydroxy-2-Methyl-, (±)-(114645-34-0)
• EPA Substance Registry System: PropanaMide, 3,3,3-trifluoro-2-hydroxy-2-Methyl-, (±)-(114645-34-0)

Safety Data

• Hazardous Substances Data: 114645-34-0(Hazardous Substances Data)

Upstream product

• 335-08-0 1,1,1-trifluoropropan-2-one cyanohydrine 
• 337-16-6 2-hydroxy-2-methyl-3,3,3-trifluoropropionic acid methyl ester 

Downstream Products

• 24435-45-8 (S)-2-trifluoromethyllactic acid 
• 374-35-6 (R)-3,3,3-trifluoro-2-hydroxy-2-methylpropionic acid 
• 242139-36-2 N-(4-cyano-2-trifluoromethylphenyl)-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide 
• 242139-35-1 N-(4-cyano-2-methylphenyl)-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide 
• 242139-34-0 2-hydroxy-2-methyl-N-(2-methyl-4-nitrophenyl)-3,3,3-trifluoropropanamide 
• 242139-33-9 N-(2-chloro-4-nitrophenyl)-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide 

Relevant articles and documents

Efficient preparation of both enantiomers of 3,3,3-trifluoro-2-hydroxy-2- methylpropanoic acid catalyzed by Shinella sp. R-6 and Arthrobacter sp. S-2

Several microorganisms that can enantioselectively hydrolyze 3,3,3-trifluoro-2-hydroxy-2-methylpropanamide have been isolated from soil samples. These strains were capable of growing in a medium containing 3,3,3-trifluoro-2-hydroxy-2-methylpropanamide as the sole nitrogen source. Among them, Shinella sp. R-6 was identified as a strain capable of exhibiting R-selective hydrolysis activity, while Arthrobacter sp. S-2 was capable of exhibiting S-selective hydrolysis activity. The preparation of both enantiomers of 3,3,3-trifluoro-2-hydroxy-2-methylpropanoic acid via the two-step whole-cell reaction was investigated using these two strains.

α-TRIFLUOROMETHYL-α-HYDROXY CARBOXYLIC ACIDS

The methyl esters of α-trifluoromethyl-α-hydroxy carboxylic acids were obtained by the reaction of methyl trifluoropyruvate with organometallic reagents (Cd, Mg, Zn).The characteristic features of the reactions in relation to the nature of the alkylating agent were demonstrated.