242139-35-1

Basic information

• Product Name: N-(4-cyano-2-methylphenyl)-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide
• CAS NO: 242139-35-1
• Molecular Weight: 272.227
• Mol File: 242139-35-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(4-cyano-2-methylphenyl)-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-cyano-2-methylphenyl)-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide(242139-35-1)
• EPA Substance Registry System: N-(4-cyano-2-methylphenyl)-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide(242139-35-1)

Safety Data

• Hazardous Substances Data: 242139-35-1(Hazardous Substances Data)

Upstream product

• 114645-34-0 (R,S)-3,3,3-trifluoro-2-hydroxy-2-methylpropionamide 
• 78881-21-7 4-amino-3-methylbenzonitrile 

Relevant articles and documents

Chemical compounds and their use to elevate pyruvate dehydrogenase activity

The use of a compound of the formula (I): wherein: ring C is phenyl or carbon-linked heteroaryl selected from pyridyl, pyrazinyl, pyrimidinyl and pyridazinyl; and wherein said phenyl or heteroaryl is substituted as defined herein; A—B is selected from NHCO, OCH2, SCH2, NHCH2, trans-vinylene, and ethynylene; R1is linked to ring C at a carbon ortho to the position of A—B attachment and is defined herein; n is 1 or 2; R2and R3are alkyl, haloalkyl or together from cycloalkyl or halocycloalkyl as defined herein; in the manufacture of a medicament for use in the elevation of PDH activity in warm-blooded animals such as humans is described. Salts and esters of compounds of formula (I) are also described.