243973-20-8Relevant articles and documents
Method for preparing 2-arylmalonic acid derivative, intermediate and application thereof
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Paragraph 0054-0055, (2020/07/15)
The invention provides a method for preparing a 2-arylmalonic acid derivative, an intermediate and application thereof. According to the method, a cyclohexadiene compound is used as a raw material, and the 2-arylmalonic acid derivative 3 is obtained through an isomerization reaction, a halogenation reaction in the presence of a halogenation reagent and a dehydrohalogenation aromatization reactionat a certain temperature in sequence. Compared with the prior art, the method has the following remarkable characteristics and advantages: (1) expensive metal catalysts are not needed in the reaction;(2) strong base with potential safety hazards is not needed in the reaction; and (3) the reaction is safe, the conditions are mild, the yield is high, the cost is low, and industrial production is facilitated.
METHOD FOR PREPARING 2-ARYL MALONAMIDE AND APPLICATIONS THEREOF
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Paragraph 0025-0026, (2020/02/13)
Disclosed are a method for preparing 2-aryl malonamide and an application thereof. This method uses 2-(cyclohexenylidene) malononitrile as a raw material, which undergoes an aromatization-hydrolyzation reaction in the presence of an oxidant and water to produce 2-aryl malonamide by one step. Compared to the prior art, the method for preparing 2-aryl malonamide of this application has the following features and advantages: (1) this method employs a completely different synthetic strategy; (2) raw materials used in this method are easily obtained; (3) this method not only has high yield, but also does not require expensive metal catalysts. This method is lower-cost, suitable for the industrial production.
Method for synthesizing pinoxaden through 2,6-diethyl-4-methylphenyl malonate
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Paragraph 0031; 0034; 0035; 0038; 0039; 0042, (2019/10/15)
The invention relates to the field of organic synthesis, in particular to a method for synthesizing pinoxaden through 2,6-diethyl-4-methylphenyl malonate. The method comprises the following steps that1, the 2,6-diethyl-4-methylphenyl malonate reacts with hydrazine hydrate to form 4-(2,6-diethyl-4-methyl)-1,2,4,5-tetrahydropyrazole-3,5-diketone; 2, the 4-(2,6-diethyl-4-methyl)-1,2,4,5-tetrahydropyrazole-3,5-diketone is subjected to cyclization with diethylene glycol dimethanesulfonate or dibromo-diethylene glycol under the effect of triethylamine to generate 8-(2,6-diethyl-4-methylbenzene)-1,2,4,5-tetrahydropyrazole[1,2-d][1,4,5]oxo-dinitrogen-7,9-diketone; 3, the 8-(2,6-diethyl-4-methylbenzene)-1,2,4,5-tetrahydropyrazole[1,2-d][1,4,5]oxo-dinitrogen-7,9-diketone reacts with pivaloyl chloride under an alkaline condition to generate the pinoxaden. The method has the advantage that the use of expensive noble metal catalysts and hypertoxic cyaniding reagents is avoided, the adopted reagents are environmentally friendly, the cost is lowered, the process is simplified, the yield is high, the defects of the prior art are overcome, and the method is suitable for large-scale industrial production.