314020-40-1

Basic information

• Product Name: 2-(2,6-diethyl-4-methyl-phenyl)propanediamide
• Synonyms: 2-(2,6-Diethyl-4-methylphenyl)malonamide; propanediamide, 2-(2,6-diethyl-4-methylphenyl)-
• CAS NO: 314020-40-1
• Molecular Formula: C₁₄H₂₀N₂O₂
• Molecular Weight: 248.32
• Mol File: 314020-40-1.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 450.8°C at 760 mmHg
• Flash Point: 226.4°C
• Density: 1.113g/cm³
• Vapor Pressure: 2.57E-08mmHg at 25°C
• Refractive Index: 1.554
• CAS DataBase Reference: 2-(2,6-diethyl-4-methyl-phenyl)propanediamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2,6-diethyl-4-methyl-phenyl)propanediamide(314020-40-1)
• EPA Substance Registry System: 2-(2,6-diethyl-4-methyl-phenyl)propanediamide(314020-40-1)

Safety Data

• Hazardous Substances Data: 314020-40-1(Hazardous Substances Data)

Usage

General Description

2-(2,6-diethyl-4-methyl-phenyl)propanediamide is a chemical compound with the molecular formula C16H26N2O. It is a white solid that is soluble in organic solvents and has a melting point of 157-159°C. 2-(2,6-diethyl-4-methyl-phenyl)propanediamide is commonly used as a pharmaceutical intermediate in the synthesis of various drugs, including analgesics and anti-inflammatory medications. It also has potential applications in the field of organic chemistry as a building block for the synthesis of more complex molecules. Additionally, 2-(2,6-diethyl-4-methyl-phenyl)propanediamide may have other industrial and commercial uses, although its exact properties and applications have not been extensively studied or documented.

Upstream product

• 24544-08-9 2,6-diethyl-4-methylaniline 
• 314020-53-6 2-(2,6-diethyl-4-methylbenzene)malononitrile 
• 314084-61-2 1-bromo-2,6-diethyl-4-methylbenzene 

Downstream Products

• 243973-20-8 pinoxaden 
• 1416807-67-4 8-(2,6-diethyl-4-methylphenyl)-3-methoxytetrahydropyrazolo[1,2-a][1,2,5]triazepine-7,9-dione 

Relevant articles and documents

METHOD FOR PREPARING 2-ARYL MALONAMIDE AND APPLICATIONS THEREOF

Disclosed are a method for preparing 2-aryl malonamide and an application thereof. This method uses 2-(cyclohexenylidene) malononitrile as a raw material, which undergoes an aromatization-hydrolyzation reaction in the presence of an oxidant and water to produce 2-aryl malonamide by one step. Compared to the prior art, the method for preparing 2-aryl malonamide of this application has the following features and advantages: (1) this method employs a completely different synthetic strategy; (2) raw materials used in this method are easily obtained; (3) this method not only has high yield, but also does not require expensive metal catalysts. This method is lower-cost, suitable for the industrial production.

Method for preparing 2-arylmalonic acid derivative, intermediate and application thereof

The invention provides a method for preparing a 2-arylmalonic acid derivative, an intermediate and application thereof. According to the method, a cyclohexadiene compound is used as a raw material, and the 2-arylmalonic acid derivative 3 is obtained through an isomerization reaction, a halogenation reaction in the presence of a halogenation reagent and a dehydrohalogenation aromatization reactionat a certain temperature in sequence. Compared with the prior art, the method has the following remarkable characteristics and advantages: (1) expensive metal catalysts are not needed in the reaction;(2) strong base with potential safety hazards is not needed in the reaction; and (3) the reaction is safe, the conditions are mild, the yield is high, the cost is low, and industrial production is facilitated.

Method for preparing 2,6-diethyl-4-methylphenylmalonamide

The invention relates to a method for preparing 2,6-diethyl-4-methylphenylmalonamide. The method comprises the following steps: catalyzing 2,6-diethyl-4-methylphenylmalonitrile and water in a polar solvent by transition metal oxides to carry out a hydrolysis reaction, thereby obtaining the 2,6-diethyl-4-methylphenylmalonamide, wherein a molar ratio of the 2,6-diethyl-4-methylphenylmalonitrile to the transition metal oxides is 1:(0.001-3.0); and the reaction temperature is 10-250 DEG C. The invention further relates to application of the 2,6-diethyl-4-methylphenylmalonamide in preparation of anherbicide pinoxaden intermediate. According to the preparation method of the 2,6-diethyl-4-methylphenylmalonamide, the 2,6-diethyl-4-methylphenylmalonitrile is subjected to catalytic hydrolysis by using the transition metal oxides, the preparation method is high in reaction speed, high in selectivity, mild in reaction condition and environmental-friendly, further hydrolysis of the product 2,6-diethyl-4-methylphenylmalonamide can be effectively avoided, and the method is suitable for industrial production.