244092-40-8

Basic information

• Product Name: Propanedioic acid, (2,6-difluoro-4-methoxyphenyl)-, diethyl ester
• CAS NO: 244092-40-8
• Molecular Formula: C14H16F2O5
• Molecular Weight: 302.275
• Mol File: 244092-40-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Propanedioic acid, (2,6-difluoro-4-methoxyphenyl)-, diethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Propanedioic acid, (2,6-difluoro-4-methoxyphenyl)-, diethyl ester(244092-40-8)
• EPA Substance Registry System: Propanedioic acid, (2,6-difluoro-4-methoxyphenyl)-, diethyl ester(244092-40-8)

Safety Data

• Hazardous Substances Data: 244092-40-8(Hazardous Substances Data)

Upstream product

• 202865-61-0 1-bromo-2,6-difluoro4-methoxybenzene 
• 123-91-1 1,4-dioxane 
• 105-53-3 diethyl malonate 

Downstream Products

• 1268821-79-9 4-(2-((6-cyano-biphenyl-3-yl)(4H-1,2,4-triazol-4-yl)amino)ethyl)-3,5-difluoro-phenyl sulfamate 
• 1268821-78-8 5-((2,6-difluoro-4-hydroxy-phenethyl)(4H-1,2,4-triazol-4-yl)amino)biphenyl-2-carbonitrile 
• 1268822-68-9 [4-(2-bromoethyl)-3,5-difluorophenoxy]triisopropylsilane 
• 1268822-67-8 2-[2,6-difluoro-4-(triisopropylsilyloxy)phenyl]ethanol 
• 1268822-66-7 methyl 2-[2,6-difluoro-4-(triisopropylsilyloxy)phenyl]acetate 
• 1268822-65-6 methyl 2-(2,6-difluoro-4-hydroxyphenyl)acetate 
• 1268822-64-5 methyl 2-(2,6-difluoro-4-methoxyphenyl)acetate 
• 886498-98-2 2-(2,6-difluoro-4-methoxyphenyl)acetic acid 
• 1268822-63-4 2-(2,6-difluoro-4-methoxyphenyl)malonic acid 
• 849550-77-2 6-{4-[4-(dimethylamino)butyl]-2,6-difluorophenyl}[1,2,4]triazolo[1,5-a]pyrimidine-5,7-diol 
• 1026235-78-8 {4-[4-(5,7-dichloro-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)-3,5-difluoro-phenyl]-butyl}-dimethyl-amine 
• 849550-76-1 diethyl 2-{4-[4-(dimethylamino)butyl]-2,6-difluorophenyl}malonate 
• 849550-74-9 diethyl 2-(2,6-difluoro-4-{[(trifluoromethyl)sulfonyl]oxy}phenyl)malonate 
• 849550-75-0 diethyl 2-[2,6-difluoro-4-(4-hydroxybutyl)phenyl]malonate 

Relevant articles and documents

6-[(SUBSTITUTED)PHENYL]TRIAZOLOPYRIMIDINES AS ANTICANCER AGENTS

This invention relates to certain 6-[(substituted)phenyl]triazolopyrimidine compounds or pharmaceutically acceptable salts thereof, and compositions containing said compounds or pharmaceutically acceptable salts thereof, wherein said compounds are anti-cancer agents useful for the treatment of cancer in mammals. This invention further relates to a method of treating or inhibiting the growth of cancerous tumor cells and associated diseases in a mammal and further provides a method for the treatment or prevention of cancerous tumors that express multiple drug resistance (MDR) or are resistant because of MDR, in a mammal in need thereof which method comprises administering to said mammal an effective amount of said compounds or pharmaceutically acceptable salts thereof. The present invention relates to a method of treating or inhibiting the growth of cancerous tumor cells and associated diseases in a mammal in need thereof by promotion of microtubule polymerization which comprises administering to said mammal an effective amount of said compounds and pharmaceutically acceptable salts thereof.