244177-70-6Relevant articles and documents
A ring-closing metathesis-based approach to the synthesis of (+)-tetrabenazine
Johannes, Manuel,Altmann, Karl-Heinz
, p. 3752 - 3755 (2012/09/07)
A modular stereoselective synthesis of the vesicular monoamine transport inhibitors (+)-tetrabenazine ((+)-1) and (+)-α-dihydrotetrabenazine ((+)-2) has been developed. The approach is based on amine 4 and acid 5 as the key building blocks, which were elaborated into macrolactam 3 by amide coupling and a subsequent highly E-selective RCM reaction. Macrolactam 3 could be converted into tetrabenazine in three known steps.
A modular synthetic approach toward exhaustively stereodiversified ligand libraries
Gierasch, Tiffany Malinky,Chytil, Milan,Didiuk, Mary T.,Park, Julie Y.,Urban, Jeffrey J.,Nolan, Steven P.,Verdine, Gregory L.
, p. 3999 - 4001 (2007/10/03)
(Matrix presented) This report describes a modular approach to the synthesis of stereodiversified natural product-like libraries. Monomers 2 and 3 were coupled in parallel by silyl-tethered olefin metathesis to generate all 16 stereoisomers of cis-enediol