1228458-05-6

Basic information

• Product Name: (5S,6R,E)-6-(tert-butyldimethylsilyloxy)-5-isobutyl-10,11-dimethoxy-2,3,5,6-tetrahydrobenzo[d]azecin-4(1H)-one
• Synonyms: (5S,6R,E)-6-(tert-butyldimethylsilyloxy)-5-isobutyl-10,11-dimethoxy-2,3,5,6-tetrahydrobenzo[d]azecin-4(1H)-one
• CAS NO: 1228458-05-6
• Molecular Weight: 447.69
• Mol File: 1228458-05-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (5S,6R,E)-6-(tert-butyldimethylsilyloxy)-5-isobutyl-10,11-dimethoxy-2,3,5,6-tetrahydrobenzo[d]azecin-4(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: (5S,6R,E)-6-(tert-butyldimethylsilyloxy)-5-isobutyl-10,11-dimethoxy-2,3,5,6-tetrahydrobenzo[d]azecin-4(1H)-one(1228458-05-6)
• EPA Substance Registry System: (5S,6R,E)-6-(tert-butyldimethylsilyloxy)-5-isobutyl-10,11-dimethoxy-2,3,5,6-tetrahydrobenzo[d]azecin-4(1H)-one(1228458-05-6)

Safety Data

• Hazardous Substances Data: 1228458-05-6(Hazardous Substances Data)

Upstream product

• 244177-70-6 (4S,5R)-3-((2S,3R)-2-isobutyl-3-hydroxypent-4-enoyl)-4-methyl-5-phenyl-1,3-oxazolidin-2-on 
• 244177-76-2 (2S,3R)-3-(tert-butyldimethylsilanyloxy)-2-isobutylpent-4-enoic acid 
• 168540-62-3 (4S,5R)-3-(4-methylpentanoyl)-4-methyl-5-phenyl-1,3-oxazolidin-2-on 
• 244177-72-8 (2S,3R)-3-hydroxy-2-isobutylpent-4-enethioic acid S-benzyl ester 
• 203806-39-7 N-(tert-butoxycarbonyl)-2-(4,5-dimethoxy-2-vinylphenyl)ethylamine 
• 120-20-7 2-(3,4-dimethoxyphenyl)-ethylamine 
• 66384-45-0 N-acetyl-2-iodo-4,5-dimethoxy-β-phenethylamine 
• 6275-29-2 N-[2-(3,4-dimethoxyphenyl)ethyl]acetamide 
• 58432-84-1 2-(2-iodo-4,5-dimethoxyphenyl)acetonitrile 
• 66384-48-3 2-(2-iodo-4,5-dimethoxyphenyl)ethan-1-amine 
• 93-17-4 3,4-dimethoxyphenylacetonitrile 
• 646-07-1 4-Methylpentanoic acid 
• 1384186-21-3 (2S,3R)-3-((tert-butyldimethylsilyl)oxy)-N-(4,5-dimethoxy-2-vinylphenethyl)-2-isobutylpent-4-enamide 
• 1384186-22-4 (2S,3R)-3-((tert-butyldimethylsilyl)oxy)-N-(2-iodo-4,5-dimethoxyphenethyl)-2-isobutylpent-4-enamide 

Relevant articles and documents

A ring-closing metathesis-based approach to the synthesis of (+)-tetrabenazine

A modular stereoselective synthesis of the vesicular monoamine transport inhibitors (+)-tetrabenazine ((+)-1) and (+)-α-dihydrotetrabenazine ((+)-2) has been developed. The approach is based on amine 4 and acid 5 as the key building blocks, which were elaborated into macrolactam 3 by amide coupling and a subsequent highly E-selective RCM reaction. Macrolactam 3 could be converted into tetrabenazine in three known steps.