58432-84-1

Basic information

• Product Name: 3,4-DiMethoxy-6-iodophenylacetonitrile
• Synonyms: 3,4-DiMethoxy-6-iodophenylacetonitrile;2-Iodo-4,5-diMethoxybenzeneacetonitrile;2-IODO-4,5-DIMETHOXYPHENYLACETONITRILE;2-(2-Iodo-4,5-dimethoxyphenyl)acetonitrile
• CAS NO: 58432-84-1
• Molecular Formula: C₁₀H₁₀INO₂
• Molecular Weight: 303.09637
• Product Categories: Aromatics;Intermediates
• Mol File: 58432-84-1.mol
• Article Data: 4

Chemical Properties

• Melting Point: 110-111 °C
• Boiling Point: 379.1±42.0 °C(Predicted)
• Appearance: /
• Density: 1.632±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 3,4-DiMethoxy-6-iodophenylacetonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-DiMethoxy-6-iodophenylacetonitrile(58432-84-1)
• EPA Substance Registry System: 3,4-DiMethoxy-6-iodophenylacetonitrile(58432-84-1)

Safety Data

• Hazardous Substances Data: 58432-84-1(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 58432-84-1 differently. You can refer to the following data:
1. As an intermediate, 3,4-DiMethoxy-6-iodophenylacetonitrile can be used in the preparation of halogenated dopamine analogues used in tissue distrubition studies.
2. An intermediate used in the preparation of halogenated dopamine analogues used in tissue distrubition studies.

Upstream product

• 58432-83-0 (4,5-dimethoxy-2-iodophenyl)methyl chloride 
• 143-33-9 sodium cyanide 
• 93-17-4 3,4-dimethoxyphenylacetonitrile 
• 151-50-8 potassium cyanide 
• 293732-19-1 (4,5-dimethoxy-2-iodophenyl)methyl bromide 

Downstream Products

• 1429322-37-1 2-(4-chlorophenyl)-5,6-dimethoxy-1-oxo-1H-indene-3-carbonitrile 
• 1429322-16-6 2-(2-((4-chlorophenyl)ethynyl)-4,5-dimethoxyphenyl)acetonitrile 
• 1384186-21-3 (2S,3R)-3-((tert-butyldimethylsilyl)oxy)-N-(4,5-dimethoxy-2-vinylphenethyl)-2-isobutylpent-4-enamide 
• 1384186-22-4 (2S,3R)-3-((tert-butyldimethylsilyl)oxy)-N-(2-iodo-4,5-dimethoxyphenethyl)-2-isobutylpent-4-enamide 
• 1228458-10-3 (2R,3S,11bR)-2-hydroxy-3-isobutyl-9,10-dimethoxy-2,3,6,7-tetrahydro-1H-pyrido[2,1-α]isoquinolin-4(11bH)-one 
• 1384186-29-1 C₄₀H₅₈N₂O₈ 
• 1228458-05-6 (5S,6R,E)-6-(tert-butyldimethylsilyloxy)-5-isobutyl-10,11-dimethoxy-2,3,5,6-tetrahydrobenzo[d]azecin-4(1H)-one 
• 1384186-23-5 C₅₂H₈₆N₂O₈Si₂ 
• 1026016-83-0 ((3R,11bR)-3-isobutyl-9.10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-one) 
• 1012326-99-6 2-(2-iodo-4,5-dimethoxyphenyl)-3,3-bis(methylthio)acrylonitrile 

Relevant articles and documents

A ring-closing metathesis-based approach to the synthesis of (+)-tetrabenazine

A modular stereoselective synthesis of the vesicular monoamine transport inhibitors (+)-tetrabenazine ((+)-1) and (+)-α-dihydrotetrabenazine ((+)-2) has been developed. The approach is based on amine 4 and acid 5 as the key building blocks, which were elaborated into macrolactam 3 by amide coupling and a subsequent highly E-selective RCM reaction. Macrolactam 3 could be converted into tetrabenazine in three known steps.

An improved stereocontrolled route to cis-erythrinanes by combined intramolecular Strecker and Bruylants reaction

Condensation of (2-iodophenyl)ethylamines with cyclohexanoylacetaldehyde provided the corresponding aldimines which were reduced yielding secondary phenethylcyclohexanoylethylamines. These in turn were appropriate intermediates to prepare several erythrin