2467-02-9Relevant articles and documents
Nano-silica?PVC-bonded N-ethyl sulfamic acid as a recyclable solid catalyst for the hydroxyalkylation of phenol with formaldehyde to bisphenol F
Jiang, Dabo,Zhou, Shuolin,Fu, Zaihui,Xu, Qiong,Xiao, Jiafu,Zheng, Min,Zhong, Wenzhou,Liu, Xianxiang,Kirk, Steven Robert,Yin, Dulin
, p. 1394 - 1403 (2019)
Sulfamic acid functionalized PVC-coated nano-silica (NS) catalyst (NS?PVC-EDA-SO3H) was prepared via multi-step treatment processes and characterized by FT-IR, N2 adsorption-desorption, TGA/DTG, XRD, TEM, STEM-EDS, as well as acid-base back-titration. The hydroxyalkylation of phenol with formaldehyde to bisphenol F was employed to evaluate in detail its acid catalysis performances. The results indicated that the newly constructed NS?PVC-EDA-SO3H possessed richer short mesoporous to macroporous channels and highly exposed sulfamic acids and could exhibit excellent hydroxyalkylation activity and reusability owing to fast mass transfer and reaction rates for the conversion of substrates, as well as excellent structural and chemical stabilities. This new solid acid was obviously superior to the conventional homogeneous concentrated sulfuric acid and heterogeneous sulfonated resin catalysts in catalytic activity and reusability, which could achieve a remarkable formaldehyde conversion (99.9%) and selectivity of bisphenol F (94.5%) under optimal hydroxyalkylation conditions. Furthermore, it could also be recovered easily and used repeatedly at least nine times without an obvious decrease in activity.
Hydroxyalkylation of phenol to bisphenol F over Al-pillared clay
Wu, Xianzhang,Xia, Xinnian,Liu, Ran,Chen, You
, p. 34625 - 34632 (2016)
Hydroxyalkylation of phenol to bisphenol F over the intercalation of aluminum hydroxy oligomeric into layered montmorillonite K10 was investigated. A remarkably high product yield (89.2%) and selectivity to bisphenol F (92.7%) has been achieved at a 110 °C reaction temperature and reaction time of 80 min with a Al-MMT(6) catalyst. A series of catalysts were prepared and characterized by FT-IR, XRD, BET, NH3-TPD and Py-IR. Characterization results showed that the catalytic performance of these catalysts depended on weak and moderate acidity and the textural properties (specific surface areas). The effect of the catalyst calcination temperature to this reaction was also studied. Moreover, the influences of various reaction parameters like mole ratio, catalyst concentration, reaction temperature and reaction time on the product yield and selectivity to bisphenol F were investigated. Finally, the reusability of the catalyst was studied and a plausible mechanistic pathway was proposed.
ION CHANNEL ANTAGONISTS/BLOCKERS AND USES THEREOF
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, (2021/06/22)
Provided are ion channel antagonists/blockers and uses thereof. Specifically, it provides the compounds of formula (I) or pharmaceutically acceptable salts, stereoisomers, solvates or prodrugs, preparation method therefor and application thereof. Definition of each group in the formula can be found in the specification for details. Provided is also pharmaceutical composition useful for treatment of heart disease and other ion channel related diseases.
For simultaneous preparation14 C mark F isomer of bisphenol (by machine translation)
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Paragraph 0038-0039, (2017/08/29)
The invention discloses a method for simultaneous preparation of14 C mark bisphenol F isomer, which belongs to the radioactive isotope14 C mark in the field of compound. The trace of the present invention synthetic method is by formaldehyde and14 C benzene ring mark of the phenol in phosphate under catalysis of condensation reaction, after the reaction, through separation and purification, to obtain14 C mark bisphenol F three kinds of isomers of 4, 4 '- dihydroxy diphenyl methane (4, 4' - BPF), 2, 4 '- dihydroxy diphenyl methane (2, 4' - BPF) and 2, 2 '- dihydroxy diphenyl methane (2, 2' - BPF). The invention has the following advantages: available reaction raw materials, the reaction phenolic ratio is low, the unreacted phenol get good recovery. The method for preparing bisphenol F isomer chemical purity is greater than 99%, radioactive purity are 2, 2 '- BPF 99.2%, 2, 4' - BPF 99.0%, 4, 4' - BPF 99.5%, can meet the follow-up study of the purity requirement for the material. (by machine translation)