24703-12-6

Basic information

• Product Name: (6beta,9xi,11beta,16beta)-9-fluoro-6,11,17,21-tetrahydroxy-16-methylpregna-1,4-diene-3,20-dione
• CAS NO: 24703-12-6
• Molecular Formula: C₂₂H₂₉FO₆
• Molecular Weight: 408.4605
• Mol File: 24703-12-6.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 613.2°C at 760 mmHg
• Flash Point: 324.6°C
• Density: 1.38g/cm³
• Vapor Pressure: 1.34E-17mmHg at 25°C
• Refractive Index: 1.608
• CAS DataBase Reference: (6beta,9xi,11beta,16beta)-9-fluoro-6,11,17,21-tetrahydroxy-16-methylpregna-1,4-diene-3,20-dione(CAS DataBase Reference)
• NIST Chemistry Reference: (6beta,9xi,11beta,16beta)-9-fluoro-6,11,17,21-tetrahydroxy-16-methylpregna-1,4-diene-3,20-dione(24703-12-6)
• EPA Substance Registry System: (6beta,9xi,11beta,16beta)-9-fluoro-6,11,17,21-tetrahydroxy-16-methylpregna-1,4-diene-3,20-dione(24703-12-6)

Safety Data

• Hazardous Substances Data: 24703-12-6(Hazardous Substances Data)

Upstream product

• 50-02-2 dexamethasone 
• 5593-20-4 betamethasone dipropionate 

Relevant articles and documents

Identification of new substrates for the CYP106A1-mediated 11-oxidation and investigation of the reaction mechanism

Abstract CYP106A1 from Bacillus megaterium DSM319 was recently shown to catalyze steroid and terpene hydroxylations. Besides producing hydroxylated steroid metabolites at positions 6β, 7β, 9α and 15β, the enzyme displayed previously unknown 11-oxidase activity towards 11β-hydroxysteroids. Novel examples for 11-oxidation were identified and confirmed by 1H and 13C NMR for prednisolone, dexamethasone and 11β-hydroxyandrostenedione. However, only 11β-hydroxyandrostenedione formed a single 11-keto product. The latter reaction was chosen to investigate the kinetic solvent isotope effect on the steady-state turnover of the CYP106A1-mediated 11-oxidation. Our results reveal a large inverse kinetic isotope effect (～0.44) suggesting the involvement of the ferric peroxoanion as a reactive intermediate.