2476-56-4

Basic information

• Product Name: TpTp
• Synonyms: TpTp
• CAS NO: 2476-56-4
• Molecular Formula: C20H28 N4 O15 P2
• Molecular Weight: 626.4
• Mol File: 2476-56-4.mol
• Article Data: 6

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.75g/cm³
• Refractive Index: 1.645
• CAS DataBase Reference: TpTp(CAS DataBase Reference)
• NIST Chemistry Reference: TpTp(2476-56-4)
• EPA Substance Registry System: TpTp(2476-56-4)

Safety Data

• Hazardous Substances Data: 2476-56-4(Hazardous Substances Data)

Usage

General Description

TpTp, also known as tris(pyrazolyl)borate, is a chemical compound containing a tridentate ligand with three pyrazolyl groups. It is commonly used as a ligand in coordination chemistry to stabilize and anchor metal ions. TpTp has been widely studied for its applications in organometallic chemistry, catalysis, and materials science. It has also been used as a precursor for the synthesis of various metal complexes with potential applications in pharmaceuticals, organic synthesis, and materials science. Furthermore, TpTp has been investigated for its potential as a chelating agent in environmental remediation and waste treatment due to its ability to form stable complexes with metal ions. Overall, TpTp has demonstrated significant versatility and potential in various chemical and industrial applications due to its unique structure and properties.

InChI:InChI=1/C20H28N4O15P2/c1-9-5-23(19(28)21-17(9)26)15-3-11(13(7-25)36-15)39-41(33,34)35-8-14-12(38-40(30,31)32)4-16(37-14)24-6-10(2)18(27)22-20(24)29/h5-6,11-16,25H,3-4,7-8H2,1-2H3,(H,33,34)(H,21,26,28)(H,22,27,29)(H2,30,31,32)/t11-,12-,13+,14+,15-,16+/m0/s1

Upstream product

• 85363-85-5 5'-O-(bis<2-(p-nitrophenyl)ethyl>phosphoryl)thymidylyl(3'-P-(2-(p-nitrophenyl)ethyl)>-5')thymidine 3'-(bis<2-(p-nitrophenyl)ethyl> phosphate) 
• 616-30-8 3-Amino-1,2-propanediol 
• 40615-39-2 5'-O-(4-4'-dimethoxytrityl)thymidine 
• 2642-43-5 thymidine 3'-monophosphate 
• 78635-91-3 Dimethyl-phosphoramidous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester methyl ester 
• 86030-46-8 C₃₆H₄₂N₃O₉P 
• 84416-85-3 [5'-O-(4,4'-dimethoxytrityl)thymidine-3'-yl]-(N,N'-diisopropyl)methylphosphoramidite 
• 86030-47-9 C₃₆H₄₂N₃O₈P 
• 42926-80-7 5'-O-(4-monomethoxytrityl)-2'-deoxythymidine 
• 70007-96-4 C₄₉H₅₇N₇O₁₄P₂S₄ 
• 78512-47-7 5'-O-(Methoxytrityl)thymidine 3'-<2-cyanoethyl S-(dimethylthiocarbamoyl)thiophosphate> 
• 78512-49-9 C₃₃H₃₅N₃O₈PS₂^(1-) 
• 78513-23-2 C₁₆H₂₃N₄O₇PS₂ 
• 85363-83-3 5'-O-(bis<2-(p-nitrophenyl)ethyl>phosphoryl)thymidine 3'-<(p-nitrophenyl)ethyl phosphate> 

Relevant articles and documents

Photochemical generation of oligodeoxynucleotide containing a C4′-oxidized abasie site and its efficient amine modification: Dependence on structure and microenvironment

(Chemical Equation Presented) Bleomycin-induced oxidative DNA damage under limited oxygen conditions results in the formation of the C4′-oxidized abasic site (1). We synthesized the oligodeoxynucleotides (ODN) 5, which contains 4′-o-nitrobenzyloxythymidine (3), and 6, which contains 2-nitrobenzyloxy-4′-methoxy-2′-deoxy-D-ribofuranoside (4) as the caged precursors of 7, an ODN containing 1, to study its reactivity with amines Photoirradiation of the single- and double-stranded 5 led to the formation of 7. Uncaging of the duplex was faster and the yield of 7 was higher with the double-stranded than with the single-stranded ODN. It was suggested that a low dielectric environment of the o-nitrobenzyloxy group in the minor groove of the duplex might accelerate the uncaging rate. Similarly, 6 and its duplex yielded 7 by photoirradiation However, the yields of 7 were lower than those of 5, and duplex formation slowed the uncaging rate. Reaction of the obtained 7 with an amine resulted in the formation of the lactam 2b in good yield in both single- and double-stranded forms, showing that amine modification of biomolecules by an ODN containing 1 is possible under physiologic conditions.

Nucleotides. Part XXVII. BisPhosphorochloridate, a New Versatile Phosphorilating Agent in Nucleotide Chemistry

A new, versatile phosphorilating agent, bis phosphorochloridate (3), has been prepared and is used for 3'- and/or 5'-phosphorylations of nucleotides.The resulting bis phosphotriesters are versatile synthons

AN INVESTIGATION OF SEVERAL DEOXYNUCLEOSIDE PHOSPHORAMIDITES USEFUL FOR SYNTHESIZING DEOXYOLIGONUCLEOTIDES

Various deoxynucleoside N,N-dialkylaminomethoxyphosphines were examined for stability and reactivity in deoxyoligonucleotide synthesis.Of those examined, the N-morpholino and N,N-diisopropylamino derivatives most completely satisfied all criteria.