24767-69-9

Basic information

• Product Name: 1-chloro-1,3-diphenylpropan-2-one
• CAS NO: 24767-69-9
• Molecular Formula: C₁₅H₁₃ClO
• Molecular Weight: 244.7161
• Mol File: 24767-69-9.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 346.1°C at 760 mmHg
• Flash Point: 200.3°C
• Density: 1.172g/cm³
• Vapor Pressure: 5.88E-05mmHg at 25°C
• Refractive Index: 1.583
• CAS DataBase Reference: 1-chloro-1,3-diphenylpropan-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-chloro-1,3-diphenylpropan-2-one(24767-69-9)
• EPA Substance Registry System: 1-chloro-1,3-diphenylpropan-2-one(24767-69-9)

Safety Data

• Hazardous Substances Data: 24767-69-9(Hazardous Substances Data)

Usage

Physical state

Pale yellow solid.

Odor

Strong and pungent.

Primary use

Tear gas and irritant agent in riot control and crowd control situations.

Effects

Acts as a lacrimator, causing intense tearing, burning, and discomfort in the eyes, skin, and respiratory system.

Potential use

As a chemical intermediate in the synthesis of pharmaceuticals, agrochemicals, and fine chemicals.

Safety measures

Proper safety measures and handling precautions should be followed when working with this chemical.

Upstream product

• 102-04-5 1,3-Diphenylpropanone 
• 64-17-5 ethanol 
• 857808-04-9 2-benzyl-3-chloro-2-hydroxy-3-phenyl-propionitrile 
• 41049-36-9 1-hydroxy-1,3-diphenylacetone 

Downstream Products

• 66551-92-6 1-acetoxy-1,3-diphenyl-acetone 
• 75524-53-7 benzyl α-fluorobenzyl ketone 
• 119515-80-9 1,1-Dichloro-1,3-diphenyl-propan-2-one 
• 856981-03-8 1,3-Dichloro-1,3-diphenyl-propan-2-one 
• 76312-47-5 2,2-bis(benzyl)-1,3-dithiolane 
• 112260-78-3 2-Phenethyl-2-phenyl-[1,3]dithiolane 
• 69897-44-5 trans-(2S,3R)-epoxy-1,3-diphenylpropan-1-one 
• 220044-16-6 1,3,5-triphenylpentane-1,4-dione 
• 1370247-58-7 1-(1H-indol-3-yl)-1,3-diphenylpropan-2-one 
• 3780-00-5 1-(3-phenyl-1,2-propadienyl)benzene 
• 112260-76-1 C₁₉H₂₄S₂ 
• 112260-74-9 C₁₉H₂₄S₂ 

Relevant articles and documents

A Simple and Efficient Method for the Preparation of α-Halogenated Ketones Using Iron(III) Chloride and Iron(III) Bromide as Halogen Sources with Phenyliodonium Diacetate as Oxidant

α-Halogenated ketones are both unique structure moieties existing in biologically natural products and valuable synthetic intermediates for the preparation of functional molecules. An efficient and scalable method for the preparation of α-halogenated ketone using iron (III) chloride and iron (III) bromide as halogen sources with phenyliodonium diacetate as oxidant has been developed, featuring mild reaction conditions, environmentally friendly reagents, and wide substrate scope. Notably, the three-step synthesis of drug prasugrel was achieved using this developed method as a key step with 30% yield on gram-scale. Additionally, the reaction mechanism involving chloride cation was proposed based on some preliminary control experiments. (Figure presented.).

THE CHLORINATION OF KETONES USING TRIMETHYLCHLOROSILANE AND DIMETHYLSULFOXIDE WITH BROMIDE ION CATALYSIS

Chlorination using trimethylchlorosilane and dimerthylsulfoxide with bromide ion catalysis afforded almost quantitative yields for 1,3-diphenylacetone, benzoylacetone and propiophenone, and acceptable yields for acetophenone, acetylacetone and cyclohexanone.