248255-98-3Relevant articles and documents
Transformation of aryl acyloin O-alkyl and O-phenyl derivatives to ketones
Yao, Zhiyi,Ye, Deju,Liu, Hong,Chen, Kaixian,Jiang, Hualiang
, p. 149 - 156 (2007)
The treatment of aryl acyloin (α-hydroxyketone) O-alkyl and O-phenyl derivatives with 2-3 equiv of Zn and 1-2 equiv of NH4Cl in ethanol, refluxing for 20-120 min, gave the corresponding ketones with excellent yields. Further, α,β-epoxy ketones can be efficiently transformed to β-hydroxy ketones, and 2,2-dialkoxy-1-phenyl ketone also can be dealkoxylated to 1-phenyl ketone. Copyright Taylor & Francis Group, LLC.
Synthesis of benzofurans from the cyclodehydration of α-phenoxy ketones mediated by Eaton’s reagent
Ma, Lin,Ma, Zhanwei,Zhang, Min,Zhou, Min
, p. 426 - 436 (2020/03/23)
Cyclodehydration of α-phenoxy ketones promoted by Eaton’s reagent (phosphorus pentoxide–methanesulfonic acid) is used to prepare 3-substituted or 2,3-disubstituted benzofurans with moderate to excellent yields under mild conditions. The method provides a facile access to benzofurans from readily available starting materials such as phenols and α-bromo ketones. The reaction is highly efficient, which is attributed to the good reactivity and fluidity of Eaton’s reagent. The reaction can be applied to prepare naphthofurans, furanocoumarins, benzothiophenes, and benzopyrans.
METALLOENZYME INHIBITOR COMPOUNDS
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Page/Page column 152, (2018/09/28)
Provided are compounds having HDAC6 modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by HDAC6.
