24833-47-4 Usage
Description
2-Benzoyl-N-(2-hydroxyethyl)-N-methylbenzamide, also known as Nefamide, is a chemical compound with a complex structure that features a benzoyl group, a hydroxyethyl group, and a methylbenzamide group. It is characterized by its potential pharmaceutical applications and is known for its ability to alleviate pain.
Uses
Used in Pharmaceutical Industry:
2-Benzoyl-N-(2-hydroxyethyl)-N-methylbenzamide is used as an active pharmaceutical ingredient for the development of analgesic medications, specifically for the treatment of moderate to severe pain. Its efficacy in pain management is attributed to its interaction with certain receptors in the central nervous system, which helps to reduce the perception of pain and provide relief to patients suffering from various types of pain conditions.
Used in Pain Management:
In the field of pain management, 2-benzoyl-N-(2-hydroxyethyl)-N-methylbenzamide is utilized as a key component in the formulation of the analgesic drug nefopam. This drug is particularly effective in managing pain associated with various conditions, such as postoperative pain, musculoskeletal pain, and neuropathic pain. The compound's ability to target specific receptors in the brain and spinal cord makes it a valuable asset in the development of effective pain relief medications.
Check Digit Verification of cas no
The CAS Registry Mumber 24833-47-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,4,8,3 and 3 respectively; the second part has 2 digits, 4 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 24833-47:
(7*2)+(6*4)+(5*8)+(4*3)+(3*3)+(2*4)+(1*7)=114
114 % 10 = 4
So 24833-47-4 is a valid CAS Registry Number.
InChI:InChI=1/C17H17NO3/c1-18(11-12-19)17(21)15-10-6-5-9-14(15)16(20)13-7-3-2-4-8-13/h2-10,19H,11-12H2,1H3
24833-47-4Relevant articles and documents
Old is Gold? Nefopam Hydrochloride, a Non-opioid and Non-steroidal Analgesic Drug and Its Practical One-Pot Synthesis in a Single Solvent for Large-Scale Production
Bodireddy, Mohan Reddy,Krishnaiah, Kiran,Babu, Prashanth Kumar,Bitra, Chaithanya,Gajula, Madhusudana Rao,Kumar, Pramod
, p. 1745 - 1751 (2017/11/24)
Nefopam hydrochloride is extensively used in most of the European countries until today as an analgesic because of its non-opiate (non-narcotic) and non-steroidal action with fewer side effects compared with opioid and other analgesics, which cause more troublesome side effects. A multikilogram synthesis of nefopam hydrochloride has been achieved in one pot using a single solvent (toluene). A ≥99.9% purity of the active pharmaceutical ingredient (API) was achieved in excellent overall yield (≥79%). The one-pot, five-step synthetic process involves formation of an acid chloride (3) from benzoylbenzoic acid (2) followed by amidation (4), reduction (5), cyclization (6), and formation of the hydrochloride salt (1). The major advantages include (i) use of a single solvent, (ii) >90% conversion in each step, (iii) a cost-effective and operationally friendly process, (iv) averting the formation of genotoxic impurities, and (v) improved overall yield (≥79%) provided by the one-pot operation. For the first time, we report the characterization data of API 1, intermediates 3, 4, and 5, and also a possible impurity (5a).
