60725-36-2

Basic information

• Product Name: 2-[[(2-hydroxyethyl)methylamino]methyl]benzhydryl alcohol
• Synonyms: 2-[[(2-hydroxyethyl)methylamino]methyl]benzhydryl alcohol;2-[[(2-Hydroxyethyl)(methyl)amino]methyl]-α-phenylbenzenemethanol;Einecs 262-391-6;2-((N-(2-hydroxyethyl)-N-methylamino)methyl)benzhydrol
• CAS NO: 60725-36-2
• Molecular Formula: C₁₇H₂₁NO₂
• Molecular Weight: 271.35414
• EINECS: 262-391-6
• Mol File: 60725-36-2.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 453.7°C at 760 mmHg
• Flash Point: 237.9°C
• Appearance: /
• Density: 1.14g/cm³
• Vapor Pressure: 5.05E-09mmHg at 25°C
• Refractive Index: 1.591
• CAS DataBase Reference: 2-[[(2-hydroxyethyl)methylamino]methyl]benzhydryl alcohol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[[(2-hydroxyethyl)methylamino]methyl]benzhydryl alcohol(60725-36-2)
• EPA Substance Registry System: 2-[[(2-hydroxyethyl)methylamino]methyl]benzhydryl alcohol(60725-36-2)

Safety Data

• Hazardous Substances Data: 60725-36-2(Hazardous Substances Data)

Usage

Type of compound

Benzhydryl alcohol derivative

Functional groups

Hydroxyethylmethylamino group attached to the benzhydryl moiety

Classification

Tertiary amine and alcohol

Potential applications

Pharmaceuticals, organic synthesis, chemical research

Biological activity

Possible significant activity in the central nervous system due to similarity with psychotropic and anxiolytic compounds

Need for further research

To fully understand its potential applications and effects

InChI:InChI=1/C17H21NO2/c1-18(12-13-19)14-17(20,15-8-4-2-5-9-15)16-10-6-3-7-11-16/h2-11,19-20H,12-14H2,1H3

Upstream product

• 24833-47-4 2-benzoyl-N-(2-hydroxyethyl)-N-methylbenzamide 
• 22103-85-1 2-benzoylbenzoyl chloride 
• 85-52-9 2-Benzoylbenzoic acid 
• 13669-70-0 nefopam 

Downstream Products

• 13669-70-0 nefopam 
• 23327-57-3 nefopam hydrochloride 

Relevant articles and documents

Old is Gold? Nefopam Hydrochloride, a Non-opioid and Non-steroidal Analgesic Drug and Its Practical One-Pot Synthesis in a Single Solvent for Large-Scale Production

Nefopam hydrochloride is extensively used in most of the European countries until today as an analgesic because of its non-opiate (non-narcotic) and non-steroidal action with fewer side effects compared with opioid and other analgesics, which cause more troublesome side effects. A multikilogram synthesis of nefopam hydrochloride has been achieved in one pot using a single solvent (toluene). A ≥99.9% purity of the active pharmaceutical ingredient (API) was achieved in excellent overall yield (≥79%). The one-pot, five-step synthetic process involves formation of an acid chloride (3) from benzoylbenzoic acid (2) followed by amidation (4), reduction (5), cyclization (6), and formation of the hydrochloride salt (1). The major advantages include (i) use of a single solvent, (ii) >90% conversion in each step, (iii) a cost-effective and operationally friendly process, (iv) averting the formation of genotoxic impurities, and (v) improved overall yield (≥79%) provided by the one-pot operation. For the first time, we report the characterization data of API 1, intermediates 3, 4, and 5, and also a possible impurity (5a).