24878-25-9Relevant articles and documents
Hydrogen bond networks in five- and eight-membered palladium and platinum complexes derived from bis(2-aminophenyl)ether and bis(2-aminophenyl)thioether ligands
Hernández-Balderas, Uvaldo,Andrade-López, Noemí,Alvarado-Rodríguez, José G.,Moreno-Esparza, Rafael,Paneque, Margarita
, p. 165 - 174 (2015)
The reaction of [MII(MeCN)2Cl2] (M = Pd, Pt) with the diamino ligands either bis(2-aminophenyl)ether or bis(2-aminophenyl)thioether {(NH2-C6H4)2D} [D = O (L1); D = S (L2)] yielded neutral coordination complexes of general formulae [M(Ln)Cl2] [M = Pd, n = 1 (1); Pt, n = 1 (2); Pd, n = 2 (3); Pd, n = 2 (4); Pt, n = 2 (5). The reaction of L2 with K2[PtCl6] promoted the mono-deprotonation of the diamino ligand to yield the neutral complex [PtIV{(NH2-C6H4)S(NH-C6H4)}Cl3] (6); when the H2[PtCl6] acid was used an ionic complex [PtIV(L2)Cl3]Cl (7) was obtained. All complexes were characterized by NMR in solution, vibrational spectroscopy, and by X-ray diffraction studies. The molecular structures of the complexes revealed different coordination patterns of the diamino ligands; L1 just displayed a κ2N mode meanwhile L2 exhibited a wide variety of patterns (κ2N, κNκS, and κ2NκS) forming chelate rings of five- or eight-members. The presence of N-H functions in the ligand moieties enhanced the formation of extended hydrogen-bond networks; these supramolecular arrangements were mainly discussed at unitary and binary levels and sorted according to the molecular coordination patterns observed.
A Comprehensive Study of the Ca2+ Ion Binding of Fluorescently Labelled BAPTA Analogues
Csomos, Attila,Kontra, Bence,Jancsó, Attila,Galbács, Gábor,Deme, Ruth,Kele, Zoltán,Rózsa, Balázs József,Kovács, Ervin,Mucsi, Zoltán
, p. 5248 - 5261 (2021/10/19)
Since its development, the ionophore BAPTA (1,2-bis(2-aminophenoxy)-ethane-N,N,N’,N’-tetraacetic acid) has been used unchanged in calcium sensing applications. In this work we present a comprehensive experimental and theoretical study of novel alterations in the structure of BAPTA, with a focus on the systematic modification of the chain connecting the two aromatic rings of the molecule (denoted as “linker”). A bis-(diethylamino)xantene fluorophore was also attached to the structures in a fixed position and the structure-fluorescence response relationship of these molecules was investigated in addition. The effect of the linker's length, the number of oxygen atoms in this chain and even the removal of one of the rings was tested; these all proved to significantly alter the characteristics of the compounds. For example, it was found that the second aromatic ring of BAPTA is not essential for the turn-on of the fluorescence. We also demonstrated that successful sensing can be realized even by replacing the chain with a single oxygen atom, which suggests the availability of a new calcium binding mode of the chelator. The reliable turn-on characteristic, the steep Ca2+ fluorescence titration curve and the intense fluorescence emission combine to make this compound a prospective candidate as a calcium sensing molecular probe in diagnostic neurobiological applications.
Metal- and Phenol-Free Synthesis of Biaryl Ethers: Access to Dibenzobistriazolo-1,4,7-oxadiazonines and Vancomycin-Like Glyco-Macrocycles as Antibacterial Agents
Singh, Kartikey,Sharma, Gaurav,Shukla, Manjulika,Kant, Ruchir,Chopra, Sidharth,Shukla, Sanjeev K.,Tripathi, Rama P.
, p. 14882 - 14893 (2018/12/14)
An efficient synthesis of biaryl ethers, from electron-deficient aryl halides using NaH/DMSO under metal- and phenol-free conditions, has been achieved to access dibenzo-bistriazolo-1,4,7-oxadiazonines and vancomycin-like glyco-macrocycles. A 44-membered glyco-macrocycle showed promising activity against vancomycin-resistant Staphylococcus aureus (VRSA).
