24891-35-8Relevant articles and documents
Reductive Formylation of Nitroarenes using HCOOH over Bimetallic C?N Framework Derived from the Integration of MOF and COF
Kumar Kar, Ashish,Srivastava, Rajendra
, p. 3174 - 3183 (2021/05/27)
CoZn embedded C?N framework is prepared by the carbonization of CoZn containing MOF integrated with COF porous architecture in Ar atmosphere. The graphitic nature of porous carbon is confirmed from Raman analysis. The porosity and nanostructure information are retrieved from N2-sorption and transmission electron microscopic analysis, respectively. The incorporation of different metals and their oxidation states and types of nitrogen present in the C?N framework are confirmed from X-ray photoelectron spectroscopy. The basicity of the materials is determined from a CO2-temperature programmed desorption. ZnCo embedded C?N framework exhibits excellent activity in the selective reductive formylation using HCOOH. For comparison, more than 15 materials are prepared, and their activities are compared. Several control experiments are performed to establish a structure-activity relation. The recycling experiment, hot-filtration test, and poisoning experiment demonstrate the metal embedded porous C?N framework‘s recyclability and stability. A reaction mechanism for the reductive N-formylation of nitroaromatics is presented based on structure-activity relationship, control reactions, and physicochemical characterizations. The development of interesting MOF-COF-derived metal nanoclusters embedded C?N framework for selective reductive formylation of nitroaromatics using formic acid will be highly attractive to catalysis researchers and industrialists.
Preparation method of mecitinib raw material (by machine translation)
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Paragraph 0052; 0053, (2020/05/30)
The method comprises the following steps: preparing,methyl 3 -(-ethyl-)-amido phenol, dichloro - 5 5-methoxyaniline (by reaction with potassium chloride) sodium 2,4 - to generate (dichloro - 5 5-methan)-methaneth, 2,4 -amidobenzylether (in a chlorine substitution reaction). 2,4 - The method comprises the following steps: reacting m-methyl-methanethinonylphenol and hydrogen peroxide, to generate, dichloro - 5 5-methoxyaniline. The method comprises the following steps of reacting m-aminophenol as a raw material to synthesize methyl chloride 2,4 - potassium, and benzoyl (and reacting; with chloromethane in, a mixture) of, sodium, chloride and methyl chloride, and reacting with chloromethane in a reaction condition. (by machine translation)
Synthetic method of bosutinib intermediate
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Paragraph 0004; 0011; 0037-0038, (2020/05/30)
The invention relates to a synthetic method of a bosutinib intermediate. The method comprises the following steps: reacting m-aminophenol with formic acid to generate 3-formamido phenol; carrying outa benzene ring chlorination reaction on 2, 4-dichloro-5-carboxamido phenol to generate 2, 4-dichloro-5-carboxamido phenol, carrying out a phenolic hydroxyl methylation reaction on the 2, 4-dichloro-5-carboxamido phenol to generate 2, 4-dichloro-5-carboxamido anisole, and removing formyl by using illumination to generate 2, 4-dichloro-5-methoxyaniline. The method has the advantages of mild reactionconditions, good selectivity, high yield, no need of purification of the intermediate, easily available raw materials, environmental protection, simplicity, high efficiency, energy saving, reductionof the production cost, improvement of the operation environment, simple operation, high automation degree, and especially easy realization of industrialization.
