1988-22-3

Basic information

• Product Name: 4-chlorophenyl formate
• Synonyms: 4-chlorophenyl formate
• CAS NO: 1988-22-3
• Molecular Weight: 156.569
• Mol File: 1988-22-3.mol
• Article Data: 15

Chemical Properties

• CAS DataBase Reference: 4-chlorophenyl formate(CAS DataBase Reference)
• NIST Chemistry Reference: 4-chlorophenyl formate(1988-22-3)
• EPA Substance Registry System: 4-chlorophenyl formate(1988-22-3)

Safety Data

• Hazardous Substances Data: 1988-22-3(Hazardous Substances Data)

Upstream product

• 1988-17-6 m-nitrophenyl formate 
• 24573-38-4 4-chlorophenolate 
• 1865-01-6 (4-nitrophenyl) formate 
• 4885-02-3 Dichloromethyl methyl ether 
• 106-48-9 4-chloro-phenol 
• 5374-05-0 (dichloromethoxy)ethane 
• 64-18-6 formic acid 
• 556-63-8 lithium formate 
• 108-90-7 chlorobenzene 
• 109-94-4 formic acid ethyl ester 
• 79-37-8 oxalyl dichloride 
• 2258-42-6 formyl acetic anhydride 
• 2565-30-2 formyl chloride 
• 104-88-1 4-chlorobenzaldehyde 

Downstream Products

• 81932-03-8 4-chloro-α,α-difluoroanisole 
• 31354-51-5 N,N'-benzene-1,2-diyldiformamide 
• 6262-22-2 N-(4-formylaminophenyl)formamide 
• 7418-32-8 N-(2-nitrophenyl)formamide 
• 102-38-5 N-(3-nitrophenyl)formamide 
• 16135-31-2 p-nitroformanilide 
• 3342-77-6 N-formylanthranilic acid 
• 607-00-1 diphenylformamide 
• 6343-54-0 N-benzylformamide 
• 4252-31-7 N-formylbenzamide 
• 201230-82-2 carbon monoxide 
• 106-48-9 4-chloro-phenol 
• 1693-39-6 N-(4-hydroxyphenyl)formamide 
• 24891-35-8 3-hydroxyformanilide 

Relevant articles and documents

Acceleration of the Dakin reaction by trifluoroacetic acid

An acceleration of the Dakin reaction caused by addition of trifluoroacetic acid is described. The modified protocol converts aromatic aldehydes to the corresponding phenols within 4 hours at room temperature by means of hydrogen peroxide in acidic medium. This acceleration is attributed to the stability of hydrogen peroxide in an acidic medium. This modified protocol provides alternative and easy access to important phenolic precursors that have been used in the synthesis of various natural products.

Direct formylation of fluorine-containing aromatics with dichloromethyl alkyl ethers

Formylations of fluorine-containing aromatic compounds with dichloromethyl alkyl ethers have been investigated. Dichloromethyl propyl ether and dichloromethyl butyl ether have been applied for the formylation of fluorine-containing anisoles to give the corresponding aldehydes in good yields. Application of these ethers is preferable to that of methyl ether, which is prepared from volatile methyl formate. Reaction of fluorine-containing phenols with these dichloromethyl alkyl ethers did not give salicylaldehyde derivatives, leading instead to corresponding aryl formates in high yields. A plausible mechanism is discussed.

Application of polydopamine sulfamic acid-functionalized magnetic Fe3O4 nanoparticles (Fe3O4@PDA-SO3H) as a heterogeneous and recyclable nanocatalyst for the formylation of alcohols and amines under solvent-free conditions

Herein, formylation of structurally different amines and alcohols with ethyl formate was carried out in the presence of a catalytic proportion of sulfonic acid supported on polydopamine (PDA)-encapsulated Fe3O4 nanoparticles as a heterogeneous, recyclable, and greatly efficient catalyst; this method provided the corresponding N-formyl compounds in good to excellent yields under solvent-free conditions. The magnetically catalytic system was recovered, by-passing the time-consuming filtration operation using an external magnet device. This procedure also increases the purity of the product and promises economic and ecological advantages. Furthermore, the recovery and reuse of the catalyst was demonstrated five times without detectable loss in the activity.