6262-22-2Relevant articles and documents
En route to molecular bracelets: The synthesis of linear pentacyclic bis(benzodiazocino)benzenes
Cheng, Ying,Liu, Qing-Xiang,Meth-Cohn, Otto
, p. 640 - 642 (2000)
The title compounds, namely dibenzo[b,b']benzo[1,2-f:4,5- f']bis[1,5]diazocines, have been synthesized in a single step in two alternative ways by application of the 'tertiary amino effect': (i) the action of bis-Vilsmeier reagents derived from N,N'-dimethyl-N,N'-diformyl-p- phenylenediamine upon 4-substituted N,N-dimethylanilines, and (ii) the action of Vilsmeier reagents derived form 4-substituted N-methylformanilides on bis(dimethylamino)benzenes.
Catalyst-Free Transamidation of Aromatic Amines with Formamide Derivatives and Tertiary Amides with Aliphatic Amines
Yin, Jiawen,Zhang, Jingyu,Cai, Changqun,Deng, Guo-Jun,Gong, Hang
supporting information, p. 387 - 392 (2019/01/11)
A simple catalyst- and promoter-free protocol has been developed for the transamidation of weakly nucleophilic aromatic amines with formamide derivatives and low-reactivity tertiary amides with aliphatic amines. This strategy is advantageous because no catalyst or promoters are needed, no additives are required, separation and purification is easy, and the reaction is scalable. Significantly, this strategy was further applied to synthesize several pharmaceutical molecules on a gram scale, and excellent yields were achieved.
Supported Palladium Nanoparticles Catalyzed Reductive Carbonylation of Nitroarenes to N-Arylformamides
Thakur, Vandna,Kumar, Ajay,Sharma, Nishtha,Shil, Arun K.,Das, Pralay
supporting information, p. 432 - 437 (2017/12/26)
A facile reductive carbonylation reaction of nitroarenes to N-arylformamide synthesis was investigated under polymer supported palladium (Pd@PS) nanoparticles catalyzed conditions. Dual role of oxalic acid dihydrate ((CO2H)2 ? 2H2O) as H2 source for hydrogenation and CO source for carbonylation reaction for desired products synthesis was critically investigated under favorable DMF solvent conditions. Several cross experiments were performed to establish the best possible hypothesis for the proposed mechanism and understanding about the involvement of CO in the reaction pathway. Further, ortho-substituted nitroarenes were found to be highly specific for facile para-hydroxylation to give corresponding para-hydroxy N-aryl formamides. (Figure presented.).