24994-04-5

Basic information

• Product Name: 5-(4-Methylphenyl)-1H-tetrazole
• Synonyms: TIMTEC-BB SBB000130;5-(4-TOLYL)-1H-TETRAZOLE;5-(4-METHYLPHENYL)TETRAZOLE;5-(4-METHYLPHENYL)-1H-TETRAAZOLE;5-(4'-METHYLPHENYL)-1H-TETRAZOLE;5-(4-METHYLPHENYL)-1H-TETRAZOLE;5-(4-METHYLPHENYL)-1H-1,2,3,4-TETRAZOLE;5-(4-METHYLPHENYL)-2H-1,2,3,4-TETRAAZOLE
• CAS NO: 24994-04-5
• Molecular Formula: C₈H₈N₄
• Molecular Weight: 160.18
• Product Categories: API intermediates;Building Blocks;Heterocyclic Building Blocks;Tetrazoles
• Mol File: 24994-04-5.mol
• Article Data: 152

Chemical Properties

• Melting Point: 250-253 °C(lit.)
• Boiling Point: 260°C
• Flash Point: 159.1 °C
• Appearance: /
• Density: 1.241 g/cm³
• Vapor Pressure: 0.000128mmHg at 25°C
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility: soluble in Dimethylformamide
• PKA: 4.44±0.10(Predicted)
• BRN: 131226
• CAS DataBase Reference: 5-(4-Methylphenyl)-1H-tetrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-Methylphenyl)-1H-tetrazole(24994-04-5)
• EPA Substance Registry System: 5-(4-Methylphenyl)-1H-tetrazole(24994-04-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 24994-04-5(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Tetrahedron Letters, 38, p. 1257, 1997 DOI: 10.1016/S0040-4039(97)00052-X

InChI:InChI=1/C8H7N4/c1-6-2-4-7(5-3-6)8-9-11-12-10-8/h2-5H,1H3/q-1

Upstream product

• 856057-22-2 5-p-tolyl-tetrazol-1-ylamine 
• 619-55-6 para-methylbenzamide 
• 104-85-8 para-methylbenzonitrile 
• 100-34-5 benzene diazonium chloride 
• 104-87-0 4-methyl-benzaldehyde 
• 3235-02-7 p-methylbenzaldehyde oxime 
• 624-31-7 4-tolyl iodide 
• 3717-15-5 p-methylbenzaldehyde oxime 
• 5720-05-8 4-methylphenylboronic acid 
• 79344-08-4 1-benzyl-5-bromo-1H-tetrazole 
• 106-42-3 para-xylene 
• 589-18-4 4-Methylbenzyl alcohol 
• 38446-63-8 2-(4-methoxyphenyl)-5-(p-tolyl)-2H-tetrazole 
• 1265831-00-2 1-(4-methoxybenzyl)-5-(p-tolyl)-1H-tetrazole 

Downstream Products

• 1874-47-1 2-(4-methylphenyl)-5-phenyl-1,3,4-oxadiazole 
• 91658-54-7 Phenyl-(5-p-tolyl-tetrazol-1-yl)-methanone 
• 91658-60-5 Phenyl-(5-p-tolyl-tetrazol-2-yl)-methanone 
• 117594-34-0 phenyl 5-(p-tolyl)tetrazol-2-yl ketone p-nitrophenylhydrazone 
• 117594-22-6 phenyl 5-(p-tolyl)tetrazol-1-yl ketone p-nitrophenylhydrazone 
• 38446-87-6 2-methyl-5-(4′-methylphenyl)tetrazole 
• 68826-33-5 1-methyl-5-(4-methylphenyl)-1H-tetrazole 
• 65358-01-2 1,3-dimethyl-6-p-tolyl-7-azalumazine 
• 76952-22-2 5-Amino-1,3-dimethyl-6-(5-p-tolyl-tetrazol-2-yl)-1H-pyrimidine-2,4-dione 
• 253341-94-5 2-Prop-2-ynyl-5-p-tolyl-2H-tetrazole 
• 97240-87-4 (5-p-Tolyl-tetrazol-2-yl)-(2,4,6-trimethyl-phenyl)-methanone oxime 
• 97240-95-4 (4-Bromo-2,6-dimethyl-phenyl)-(5-p-tolyl-tetrazol-2-yl)-methanone oxime 
• 97240-91-0 (2,6-Dimethyl-phenyl)-(5-p-tolyl-tetrazol-2-yl)-methanone oxime 
• 97240-83-0 (4-Methoxy-2,6-dimethyl-phenyl)-(5-p-tolyl-tetrazol-2-yl)-methanone oxime 

Relevant articles and documents

KIT-6-anchored sulfonic acid groups as a heterogeneous solid acid catalyst for the synthesis of aryl tetrazoles

In the current study, a simple, environmentally benign and cost-effective method is presented for the preparation of 5-substituted-1H-aryltetrazoles. To this goal, mesoporous KIT-6 silica anchored with sulfonic acid (–SO3H) groups via post-grafting modification was synthesized using the sol–gel method and characterized by XRD, TGA, FTIR, BET, TEM and SEM techniques. For the preparation of tetrazole derivatives, the effect of various parameters such as catalyst amount, aryl nitrile:azide ratio, temperature and reaction time was tested. The hybrid organic/inorganic catalyst could be recovered easily through a simple filtration and reused multiple times without significant loss in activity.

CuO–NiO bimetallic nanoparticles supported on graphitic carbon nitride with enhanced catalytic performance for the synthesis of 1,2,3-triazoles, bis-1,2,3-triazoles, and tetrazoles in parts per million level

The unification of CuCl2·2H2O and NiCl2·6H2O with the support of graphitic carbon nitride yielded to form an efficient, synergistic, bimetallic nano-catalyst CuO–NiO@g-C3N4. FT-IR, SEM, TEM

Fe3O4@L-lysine-Pd(0) organic–inorganic hybrid: As a novel heterogeneous magnetic nanocatalyst for chemo and homoselective [2 + 3] cycloaddition synthesis of 5-substituted 1H-tetrazoles

An efficient and sustainable synthetic protocol has been presented to synthesis and 5-substituted 1H-tetrazole privileged heterocyclic substructures. The synthetic protocol involves two-component reaction between aryl nitriles and NaN3 in water using complex of L-lysine-palladium nanoparticles (NPs) modified Fe3O4 nanoparticles as magnetically separable, recyclable, and reusable heterogeneous catalyst. Magnetically retrievable L-lysine-Pd(0) modified Fe3O4 nanoparticles were applied in [2 + 3] cycloaddition synthesis of 5-substituted 1H-tetrazoles. The advantages of this strategy include easy recovery and efficient reusability of the expensive Pd NPs, obtaining high yields of [2 + 3] cycloaddition, short reaction times, and all of the reported synthetic strategies are being performed in water as green solvent for a wide range of substrates.