2503-32-4Relevant articles and documents
Preparation of chiral right-half models of antitumor bistetrahydroisoquinolinequinone natural products
Senbonmatsu, Yuki,Kimura, Shinya,Akiba, Megumi,Ando, Shingo,Saito, Naoki
, p. 1050 - 1067 (2019/07/31)
– The preparation of chiral right-half model compounds of bistetrahydroisoquinolinequinone natural products having a lactam carbonyl group (-)-1 or an aminonitrile group (+)-2 from (-)-14 was presented. The crucial steps of this synthesis include the N-methylation of compound (-)-12 and ring closure to generate (-)-19a without any epimerization at C-2.1
Phosphine-based redox catalysis in the direct traceless staudinger ligation of carboxylic acids and azides
Kosal, Andrew D.,Wilson, Erin E.,Ashfeld, Brandon L.
supporting information, p. 12036 - 12040 (2013/01/16)
Redox catalysis: Aryl amides, imides, lactams, and dipeptides are obtained through a direct Staudinger ligation mediated by phosphine-based redox catalysis (see scheme). Mechanistic studies indicate the involvement of a phosphonium carboxylate intermediate that leads to a 1,3-acyl migration and thus results in C-N bond formation. Copyright
A flow reactor process for the synthesis of peptides utilizing immobilized reagents, scavengers and catch and release protocols
Baxendale, Ian R.,Ley, Steven V.,Smith, Christopher D.,Tranmer, Geoffrey K.
, p. 4835 - 4837 (2007/10/03)
A general flow process for the multi-step assembly of peptides has been developed and this procedure has been used to successfully construct a series of Boc, Cbz and Fmoc N-protected dipeptides in excellent yields and purities, including an extension of t