25063-46-1

Basic information

• Product Name: 5-[(4-Chloro-phenylaMino)-Methylene]-2,2-diMethyl-[1,3]dioxane-4,6-dione
• Synonyms: 5-[(4-Chloro-phenylaMino)-Methylene]-2,2-diMethyl-[1,3]dioxane-4,6-dione;5-[(4-chloroanilino)methylidene]-2,2-dimethyl-1,3-dioxane-4,6-dione
• CAS NO: 25063-46-1
• Molecular Formula: C₁₃H₁₂ClNO₄
• Molecular Weight: 281.69168
• Mol File: 25063-46-1.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 479.7±45.0 °C(Predicted)
• Appearance: /
• Density: 1.433±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: -1.56±0.40(Predicted)
• CAS DataBase Reference: 5-[(4-Chloro-phenylaMino)-Methylene]-2,2-diMethyl-[1,3]dioxane-4,6-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 5-[(4-Chloro-phenylaMino)-Methylene]-2,2-diMethyl-[1,3]dioxane-4,6-dione(25063-46-1)
• EPA Substance Registry System: 5-[(4-Chloro-phenylaMino)-Methylene]-2,2-diMethyl-[1,3]dioxane-4,6-dione(25063-46-1)

Safety Data

• Hazardous Substances Data: 25063-46-1(Hazardous Substances Data)

Upstream product

• 15568-86-2 5-(ethoxymethylene)-2,2-dimethyl-1,3-dioxane-4,6-dione 
• 106-47-8 4-chloro-aniline 
• 2033-24-1 cycl-isopropylidene malonate 
• 56638-72-3 (E)-N'-(4-chlorophenyl)-N,N-dimethylformimidamide 
• 149-73-5 trimethyl orthoformate 
• 15568-85-1 5-methoxymethylene-2,2-dimethyl-1,3-dioxane-4,6-dione 

Downstream Products

• 21921-70-0 6-chloroquinolin-4(1H)-one 
• 4203-18-3 4,6-dichloroquinoline 
• 23432-43-1 6-chloro-4-hydroxyquinoline 

Relevant articles and documents

A Selective and Orally Bioavailable Quinoline-6-Carbonitrile-Based Inhibitor of CDK8/19 Mediator Kinase with Tumor-Enriched Pharmacokinetics

Senexins are potent and selective quinazoline inhibitors of CDK8/19 Mediator kinases. To improve their potency and metabolic stability, quinoline-based derivatives were designed through a structure-guided strategy based on the simulated drug–target dockin

Novel process for synthesizing 4-hydroxy-6-chloroquinoline

The invention belongs to the technical field of synthesis of 4-hydroxy-6-chloroquinoline, and particularly relates to a novel process for synthesizing 4-hydroxy-6-chloroquinoline. The process comprises the following steps: S1, cleaning a first reaction container, drying and cooling the container to room temperature, adding parachloroaniline and 5-(methoxymethylene)-2, 2-dimethyl-1, 3-dioxo-4, 6-diketone into an ethanol solution with a certain concentration according to a molar ratio of (0.1-1):(0.1-1), performing slow stirring, and performing reacting for 4-6 hours until the reaction is finished; S2, carrying out suction filtration on the reaction product to obtain 80-95% A; S3, adding a certain amount of diphenyl ether-biphenyl eutectic into a second reaction container, heating the container to 240-260 DEG C, adding the product A, performing stirring,performing reacting for 5-10 minutes, and performing cooling to room temperature; and S4, carrying out suction filtration on a product obtained in the S3 in petroleum ether to obtain 80-90% 4-hydroxy-6-chloroquinoline, and performing drying to obtain a 4-hydroxy-6-chloroquinoline product. According to the method disclosed by the invention, spin-drying is changed into suction filtration, so that a solid product with very high purity can be obtained, and the time is also saved; and in addition, the diphenyl ether-biphenyl eutectic is used as the solvent, so that time, manpower and material resources can be saved.

Direct C-3-alkenylation of quinolones via palladium-catalyzed C-H functionalization

An unprecedented C-3-alkenylation of quinolones was reported through palladium-catalyzed C-H functionalization with 1% catalyst loading. This method provides an efficient route to a variety of new quinolone derivatives.