251294-92-5

Basic information

• Product Name: (E)-[6-Chloro-3-(methylamino)-2-pyridyl]-3-phenylprop-2-en-1-ol
• Synonyms: (E)-[6-Chloro-3-(methylamino)-2-pyridyl]-3-phenylprop-2-en-1-ol
• CAS NO: 251294-92-5
• Molecular Weight: 274.75
• Mol File: 251294-92-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (E)-[6-Chloro-3-(methylamino)-2-pyridyl]-3-phenylprop-2-en-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-[6-Chloro-3-(methylamino)-2-pyridyl]-3-phenylprop-2-en-1-ol(251294-92-5)
• EPA Substance Registry System: (E)-[6-Chloro-3-(methylamino)-2-pyridyl]-3-phenylprop-2-en-1-ol(251294-92-5)

Safety Data

• Hazardous Substances Data: 251294-92-5(Hazardous Substances Data)

Upstream product

• 5350-93-6 6-Chloro-pyridin-3-ylamine 
• 104-55-2 3-phenyl-propenal 
• 120739-84-6 5-Amino-2-chloro-N-methylpyridine 

Downstream Products

• 251295-12-2 N-{2-[(E)-1-{[1-(tert-Butyl)-1,1-dimethylsilyl]oxy}-3-phenyl-prop-2-enyl]-6-chloro-3-pyridyl}-N-methylamine 

Relevant articles and documents

Ortho-hydroxyalkylation of aminopyridines: A novel approach to heterocycles

Reaction of 6-substituted N-alkyl-3-aminopyridines with aldehydes in the presence of dichlorophenylborane gives selectively 2-hydroxyalkyl-3- aminopyridines. Dehydration of the latter under pyrolytic or Lewis acid conditions generates a quinone methide imine intermediate which can undergo electrocyclic or [4+2] cycloaddition reactions to give naphthyridines, dihydronaphthyridines or tetrahydronaphthyridines. Palladium-catalyzed cyclization of the 2-(1-hydroxyallyl)-3-aminopyridines gives the corresponding 4-azaindoles.