120739-84-6

Basic information

• Product Name: 3-Pyridinamine,6-chloro-N-methyl-(9CI)
• Synonyms: 3-Pyridinamine,6-chloro-N-methyl-(9CI);6-chloro-N-methyl-3-Pyridinamine;3-PyridinaMine, 6-chloro-N-Methyl-;6-chloro-N-methylpyridin-3-amine
• CAS NO: 120739-84-6
• Molecular Formula: C₆H₇ClN₂
• Molecular Weight: 142.59
• Product Categories: PYRIDINE
• Mol File: 120739-84-6.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 275.7°C at 760 mmHg
• Flash Point: 120.5°C
• Appearance: /
• Density: 1.25g/cm³
• Vapor Pressure: 0.00503mmHg at 25°C
• Refractive Index: 1.596
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-Pyridinamine,6-chloro-N-methyl-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Pyridinamine,6-chloro-N-methyl-(9CI)(120739-84-6)
• EPA Substance Registry System: 3-Pyridinamine,6-chloro-N-methyl-(9CI)(120739-84-6)

Safety Data

• Hazardous Substances Data: 120739-84-6(Hazardous Substances Data)

Usage

General Description

3-Pyridinamine,6-chloro-N-methyl-(9CI) is a chemical compound, more commonly known by its CAS number: 1126-79-0. It belongs to the category of various organic compounds, particularly those known as pyridines and derivatives. 3-Pyridinamine,6-chloro-N-methyl-(9CI) consists of a pyridine ring, which is a basic six-membered ring with one nitrogen atom and five carbon atoms, that is substituted by a chlorino and a methylamino group at position 6 and 3 respectively. Due to its molecular structure, it's used in chemistry for various reactions and synthesis. However, its exact properties, effects, and potential uses are subject to further research and information.

InChI:InChI=1/C6H7ClN2/c1-8-5-2-3-6(7)9-4-5/h2-4,8H,1H3

Upstream product

• 5350-93-6 6-Chloro-pyridin-3-ylamine 
• 74-88-4 methyl iodide 
• 206006-29-3 N-(6-chloro-pyridin-3-yl)-formamide 
• 67-56-1 methanol 
• 4548-45-2 2-chloro-5-nitropyridine 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 251294-92-5 (E)-[6-Chloro-3-(methylamino)-2-pyridyl]-3-phenylprop-2-en-1-ol 
• 1104455-11-9 N₄-(6-chloropyridin-3-yl)-N₂-(3,5-dimorpholinophenyl)-N₄-methylpyrimidine-2,4-diamine 
• 290297-26-6 netupitant 
• 401891-55-2 2-(3,5-bis(trifluoromethyl)phenyl)-N-(6-chloro-4-(o-tolyl)pyridin-3-yl)-N,2-dimethylpropanamide 
• 251295-12-2 N-{2-[(E)-1-{[1-(tert-Butyl)-1,1-dimethylsilyl]oxy}-3-phenyl-prop-2-enyl]-6-chloro-3-pyridyl}-N-methylamine 
• 1610671-48-1 6-N-(6-chloropyridin-3-yl)-6-N-methyl-3-N-[4-(trifluoromethyl)phenyl]imidazo[1,2-a]pyrazine-3,6-dicarboxamide 

Relevant articles and documents

Selective N -monomethylation of primary anilines with the controllable installation of N -CH2D, N -CHD2, and N -CD3units

The selective N-monomethylation of primary anilines was realized by the use of the Me3N-BH3/N,N-dimethylformamide (DMF) system as the methyl source. This method also allows for the controllable introduction of N-CH2D, N-CHD2, and N-CD3 units with high lev

Method for preparing netupitant

The invention discloses a method for preparing netupitant, and belongs to the field of medicine compounds. The method includes the steps: performing condensation on 2-chloro-5-aminopyridine and formicacid; performing reduction, Boc protection and iodination; performing coupling and deprotection and then performing condensation on products and 2-(3, 5-bis-trifluoromethyl-phenyl)-2-methyl propionicacid; performing substitution on products and N-methylpiperazine to obtain the netupitant. The method has the advantages that the steps of processes for preparing the netupitant have fewer side effects, the method is high in yield and less in environmental pollution, after-treatment is simple, and the netupitant which is a product prepared by the aid of the method is high in purity and low in individual impurity content.

Ortho-hydroxyalkylation of aminopyridines: A novel approach to heterocycles

Reaction of 6-substituted N-alkyl-3-aminopyridines with aldehydes in the presence of dichlorophenylborane gives selectively 2-hydroxyalkyl-3- aminopyridines. Dehydration of the latter under pyrolytic or Lewis acid conditions generates a quinone methide imine intermediate which can undergo electrocyclic or [4+2] cycloaddition reactions to give naphthyridines, dihydronaphthyridines or tetrahydronaphthyridines. Palladium-catalyzed cyclization of the 2-(1-hydroxyallyl)-3-aminopyridines gives the corresponding 4-azaindoles.