252057-02-6

Basic information

• Product Name: 1,2-O-isopropylidene-3,6-di-O-trityl-α-D-glucofuranose
• Synonyms: 1,2-O-isopropylidene-3,6-di-O-trityl-α-D-glucofuranose
• CAS NO: 252057-02-6
• Molecular Weight: 704.863
• Mol File: 252057-02-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1,2-O-isopropylidene-3,6-di-O-trityl-α-D-glucofuranose(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-O-isopropylidene-3,6-di-O-trityl-α-D-glucofuranose(252057-02-6)
• EPA Substance Registry System: 1,2-O-isopropylidene-3,6-di-O-trityl-α-D-glucofuranose(252057-02-6)

Safety Data

• Hazardous Substances Data: 252057-02-6(Hazardous Substances Data)

Upstream product

• 76-83-5 trityl chloride 
• 252057-03-7 1,2-O-isopropylidene-5,6-di-O-trityl-α-D-glucofuranose 
• 18549-40-1 1,2-O-isopropylidene-α-D-glucofuranose 

Downstream Products

• 33737-08-5 1,2-O-isopropylidene-6-O-trityl-α-D-glucofuranoside 

Relevant articles and documents

Temperature dependence of the distribution of trityl groups in the tritylation of 1,2-O-isopropylidene-α-D-glucofuranose

The tritylation reaction of 1,2-O-isopropylidene-α-D-glucofuranose with 2.4 molar amounts of trityl chloride in pyridine at 70 °C for 20 h gave the 5,6-di-O-trityl derivative in 50% yield as the major product, whereas the reaction at 115 °C mainly gave the 3,6-di-O-trityl derivative (26% yield) along with the 6-O-trityl derivative (48% yield). The fact that the yield of the 5,6-di-O-trityl derivative at 115 °C decreased after 1 h and was 12% at 20 h is due to the redistribution of trityl groups including detritylation assisted by pyridinium chloride. It was found that tritylation of the primary hydroxyl group at C-6 was almost completed within 10 min at 115 °C.