25291-41-2

Basic information

• Product Name: N-Acetylcyclopentane-1-amine
• Synonyms: N-Acetylcyclopentane-1-amine;N-Cyclopentylacetamide
• CAS NO: 25291-41-2
• Molecular Formula: C₇H₁₃NO
• Molecular Weight: 127.18
• Mol File: 25291-41-2.mol
• Article Data: 17

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-Acetylcyclopentane-1-amine(CAS DataBase Reference)
• NIST Chemistry Reference: N-Acetylcyclopentane-1-amine(25291-41-2)
• EPA Substance Registry System: N-Acetylcyclopentane-1-amine(25291-41-2)

Safety Data

• Hazardous Substances Data: 25291-41-2(Hazardous Substances Data)

Usage

Description

N-Acetylcyclopentane-1-amine is an organic compound with the molecular formula C7H13NO. It is a derivative of cyclopentane, an amine with an acetyl group attached. N-Acetylcyclopentane-1-amine is known for its potential applications in various industries due to its unique chemical properties.

Uses

Used in Pharmaceutical Industry:
N-Acetylcyclopentane-1-amine is used as an intermediate in the synthesis of various pharmaceutical compounds. Its ability to form stable bonds with other molecules makes it a valuable component in the development of new drugs.
Used in Chemical Synthesis:
N-Acetylcyclopentane-1-amine is used as a reagent in the preparation of inhibitors of phosphopantetheine. Phosphopantetheine is a key component in the active sites of many enzymes, and its inhibition can have significant effects on various biological processes. N-Acetylcyclopentane-1-amine's role in the synthesis of such inhibitors highlights its importance in the field of biochemistry and drug development.
Used in Research and Development:
Due to its unique structure and properties, N-Acetylcyclopentane-1-amine is also used in research and development for exploring new chemical reactions and understanding the behavior of similar compounds. This can lead to the discovery of new applications and uses in various industries.

Upstream product

• 75-36-5 acetyl chloride 
• 1003-03-8 Cyclopentamine 
• 60-35-5 acetamide 
• 142-29-0 cyclopentene 
• 75-05-8 acetonitrile 
• 920-37-6 2-Chloroacrylonitrile 
• 96-41-3 Cyclopentanol 
• 108-22-5 Isopropenyl acetate 
• 140-11-4 Benzyl acetate 
• 74-90-8 hydrogen cyanide 
• 3400-45-1 cyclopentanecarboxylic acid 
• 287-92-3 Cyclopentane 
• 1048692-95-0 2-azido-4,4,4,5-tetramethyl-1,3,2-dioxaborolane 
• 137-43-9 Cyclopentyl bromide 

Downstream Products

• 1177860-04-6 cyclopentyl ethylamine hydrochloride 

Relevant articles and documents

Decarboxylative Ritter-Type Amination by Cooperative Iodine (I/III)─Boron Lewis Acid Catalysis

Recent years have witnessed important progress in synthetic strategies exploiting the reactivity of carbocations via photochemical or electrochemical methods. Yet, most of the developed methods are limited in their scope to certain stabilized positions in molecules. Herein, we report a metal-free system based on the iodine (I/III) catalytic manifold, which gives access to carbenium ion intermediates also on electronically disfavored benzylic positions. The unusually high reactivity of the system stems from a complexation of iodine (III) intermediates with BF3. The synthetic utility of our decarboxylative Ritter-type amination protocol has been demonstrated by the functionalization of benzylic as well as aliphatic carboxylic acids, including late-stage modification of different pharmaceutical molecules. Notably, the amination of ketoprofen was performed on a gram scale. Detailed mechanistic investigations by kinetic analysis and control experiments suggest two mechanistic pathways.

SMALL MOLECULE ACTIVATORS OF NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT) AND USES THEREOF

Provided herein are small molecule activators of Nicotinamide Phosphoribosyltransferase (NAMPT), compositions comprising the compounds, and methods of using the compounds and compositions.

Tandem synthesis of amides and secondary amines from esters with primary amines under solvent-free conditions

An iridium(III)-catalyzed tandem synthesis of amides and amines from esters under solvent-free conditions is described. A commercially available iridium(III) complex, [Cp*IrCl2]2, with sodium acetate showed the best activity for the synthesis of amides and secondary amines. The amide was formed by ester-amide exchange which generates an alcohol in situ which is subsequently transformed to a secondary amine via hydrogen autotransfer. This synthetic protocol with high atom economy generates water as the sole by-product and can afford amides and amines from various esters in a one-pot reaction, expanding the synthetic versatility of ester transformations.