25406-64-8

Basic information

• Product Name: Morroniside
• Synonyms: Morroniside;(1S,3R,4aS,8S,8aS)-8-(beta-D-Glucopyranosyloxy)-4,4a,8,8a-tetrahydro-3-hydroxy-1-methyl-1H,3H-pyrano[3,4-c]pyran-5-carboxylic acid methyl ester;8-(β-D-Glucopyranosyloxy)-4,4a,8,8a-tetrahydro-3-hydroxy-1-methyl-1H,3H-pyrano[3,4-c]pyran-5-carboxylic acid methyl ester;Morronisid;Morroniside, 98%, from Cornus officinalis Sieb. et Zucc.
• CAS NO: 25406-64-8
• Molecular Formula: C₁₇H₂₆O₁₁
• Molecular Weight: 406.38
• Product Categories: chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract
• Mol File: 25406-64-8.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 635.6oC at 760 mmHg
• Flash Point: 226.9oC
• Appearance: /
• Density: 1.52
• Vapor Pressure: 7.9E-19mmHg at 25°C
• Refractive Index: 1.596
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 12.54±0.70(Predicted)
• Stability: Hygroscopic
• CAS DataBase Reference: Morroniside(CAS DataBase Reference)
• NIST Chemistry Reference: Morroniside(25406-64-8)
• EPA Substance Registry System: Morroniside(25406-64-8)

Safety Data

• Hazardous Substances Data: 25406-64-8(Hazardous Substances Data)

Usage

Description

Morroniside, also known as Dendrobium extract, is a natural compound derived from the Dendrobium nobile orchid. It is characterized by its ability to enhance microvascular functional integrity and improve vascular elements of the neurovascular unit. Morroniside has been recognized for its potential in the treatment of cerebral ischemia and other related conditions.

Uses

Used in Pharmaceutical Industry:
Morroniside is used as a pharmaceutical agent for improving microvascular functional integrity and vascular elements of the neurovascular unit. This application is particularly relevant in the treatment of cerebral ischemia, where it can help enhance blood flow and reduce the risk of stroke-related complications.
In the treatment of cerebral ischemia, Morroniside is used as a therapeutic agent to:
1. Enhance microvascular functional integrity, which is crucial for maintaining proper blood flow and oxygen supply to the brain.
2. Improve vascular elements of the neurovascular unit, which is essential for the overall health and function of the brain.
Morroniside's role in the pharmaceutical industry is significant, as it offers a natural and potentially effective treatment option for patients suffering from cerebral ischemia and related conditions. Further research and development in this area may lead to the discovery of additional applications and benefits of Morroniside in various medical fields.

InChI:InChI=1/C17H26O11/c1-6-11-7(3-10(19)26-6)8(15(23)24-2)5-25-16(11)28-17-14(22)13(21)12(20)9(4-18)27-17/h5-7,9-14,16-22H,3-4H2,1-2H3/t6-,7+,9+,10+,11+,12+,13-,14+,16-,17-/m0/s1

Downstream Products

• 945721-10-8 7-O-ethylmorroniside 
• 41679-97-4 7-O-methylmorroniside 

Relevant articles and documents

INTERMEDIACY OF 6-HYDROXYLOGANIN IN THE RING CLEAVAGE COURSE OF LOGANIN TO SECOLOGANIN

A possible biosynthetic pathway from loganin to secologanin through ring cleavage of 6-hydroxyloganin was ruled out in feeding experiments in which Eustoma russellianum, Swertia japonica, Lonicera morrowii and Adina pilulifera were each presented with three C-6 and C-7 stereoisomers of hydroxy -loganin as well as - and -loganin.In an associated experiment, the reduction of the aldehyde group of secologanin leading to sweroside was shown to proceed by hydride ion attack from the si face.Key Word Index - Biosynthesis; ring cleavage; loganin; 6,7-stereoisomer of 6-hydroxyloganin; secologanin; stereochemical course of the reduction; deuterium labelling.