945721-10-8 Usage
Description
7-O-Ethylmorroniside is a derivative of Morroniside (M725700), a pharmaceutical agent that enhances microvascular functional integrity and vascular elements of the neurovascular unit, playing a crucial role in the treatment of cerebral ischemia.
Used in Pharmaceutical Industry:
7-O-Ethylmorroniside is used as a pharmaceutical agent for improving microvascular functional integrity and vascular elements of the neurovascular unit, which aids in the treatment of cerebral ischemia.
Check Digit Verification of cas no
The CAS Registry Mumber 945721-10-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,4,5,7,2 and 1 respectively; the second part has 2 digits, 1 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 945721-10:
(8*9)+(7*4)+(6*5)+(5*7)+(4*2)+(3*1)+(2*1)+(1*0)=178
178 % 10 = 8
So 945721-10-8 is a valid CAS Registry Number.
945721-10-8Relevant articles and documents
Synthesis and promotion of the osteoblast proliferation effect of morroniside derivatives
Han, Hua,Li, ZhengQing,Qu, Na,Chen, Si,Dong, PeiLiang
, (2018/06/15)
Sambucus williamsii Hance has been used in fractures for thousands of years, but research on its active components, such as morroniside, until now had not been carried out. In this study, morroniside was taken as the leading compound, and fourteen derivatives were synthesized. The promotion of osteoblast proliferation effect of the derivatives was evaluated on MC3T3-E1 cells. Five derivatives (2, 3, 4, 5, and 14) showed a good proliferation effect on MC3T3-E1 cells, and their promoted expression effects on OC (Osteocalcin) and ALP (Alkaline phosphatase) in MC3T3-E1 cells were measured. Compound 3 was shown to have the strongest proliferation effect (EC50 = 14.78 ± 1.17 μg/mL) and to significantly promote the expression of OC and ALP.