2544-06-1 Usage
Description
3-Methoxypropionic acid, an alkoxy acid, is a chemical compound derived from the base-catalyzed methanolysis of 1-nitroso-5,6-dihydrouracil, a potent liver carcinogen. It features a unique structure with a methoxy group attached to a propionic acid backbone, which may contribute to its potential applications in various industries.
Uses
Used in Pharmaceutical Industry:
3-Methoxypropionic acid is used as an intermediate compound for the synthesis of various pharmaceutical products. Its ability to be derived from a potent carcinogen suggests that it may have applications in the development of cancer treatments or in the study of carcinogenic processes.
Used in Chemical Synthesis:
3-Methoxypropionic acid is used as a building block in the synthesis of more complex organic molecules. Its unique structure, including the methoxy group and the propionic acid backbone, can be utilized to create a variety of compounds with different properties and applications.
Used in Research and Development:
3-Methoxypropionic acid serves as a valuable research tool for studying the properties and reactions of alkoxy acids. It can be used to investigate the effects of structural modifications on the reactivity and stability of these compounds, contributing to the advancement of chemical knowledge in this area.
Used in Solubility Enhancement:
3-Methoxypropionic acid, when combined with PEG linkers such as m-PEG1-acid, can be used to increase the solubility of compounds in aqueous media. The hydrophilic PEG spacer, along with the terminal carboxylic acid, can form stable amide bonds with primary amine groups, potentially improving the solubility and bioavailability of drug candidates.
Check Digit Verification of cas no
The CAS Registry Mumber 2544-06-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,5,4 and 4 respectively; the second part has 2 digits, 0 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 2544-06:
(6*2)+(5*5)+(4*4)+(3*4)+(2*0)+(1*6)=71
71 % 10 = 1
So 2544-06-1 is a valid CAS Registry Number.
InChI:InChI=1/C4H8O3/c1-7-3-2-4(5)6/h2-3H2,1H3,(H,5,6)
2544-06-1Relevant articles and documents
Degenerate Transesterification of 3,5-Dimethylphenolate/3,5-Dimethylphenyl Esters in Weakly Polar, Aprotic Solvents. Reactions of Aggregates and Complex-Induced Proximity Effects
Jackman,Petrei,Smith
, p. 3451 - 3458 (2007/10/02)
The rates of exchange of the 3,5-dimethylphenolate ion between lithium 3,5-dimethylphenolate-d6 and a series of 3,5-dimethylphenyl esters have been determined in the weakly polar, aprotic solvents dioxolane, dimethoxyethane (DME), tetrahydrofuran (THF), and pyridine. The esters include the propionate, butyrate, methoxyacctate, β-methoxypropionate, 4-methoxybutyrate, 2-tetrahydrofuroate, 2-furoate, (N,N-dimethylamino)acetate, (methylthio)acetate, 2- and 4-pyridine-carboxylates, 2-pyridylacetate, 4-pyridylacetate, phenylacetate, andp-methoxy-,p-chloro-, and p-(trifluoromethyl)phenylacetates. The rates and kinetic orders of the reactions of 3,5-dimethylphenyl propionate in various solvents at 35°C gave the following second-order rate constants (104k2, L mol-1 sec-1) for the following major aggregate species: THF tetramer, 6.5; DME tetramer, 3.3 (40°C); dioxolane, 13, hexamer, 71; pyridine tetramer, 2.2, dimer, 29. For 3,5-dimethylphenyl β-methoxypropionate, the order of reactivity is dioxolane > DME > THF. These results are interpreted in terms of a preequilibrium in which a solvent on lithium in the tetramer is replaced by the ester. The rates of transesterification have been compared with the rates of hydrolysis in 30% aqueous ethanol for the above series of esters. Those esters that have a second Lewis base center proximal to the ester function show significantly increased reactivity in transesterification, which is attributed to a complex-induced proximity effect.
