25447-66-9 Usage
Uses
Dihydro α-Ergocryptine is a hydrogenated ergot alkaloids, specifically an equiproportional mixture of dihydroergocornine methanesulfonate, dihydroergocristine methanesulfonate, α and β-dihydroergocrytine methanesulfonate in the ratio of 1.5-2.5:1. Dihydro α-Ergocryptine is an α-adrenergic blocker used for the treatment of impaired mental function in the elderly.
Definition
ChEBI: alpha-Ergocryptine in which a single bond replaces the double bond between positions 9 and 10.
Check Digit Verification of cas no
The CAS Registry Mumber 25447-66-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,5,4,4 and 7 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 25447-66:
(7*2)+(6*5)+(5*4)+(4*4)+(3*7)+(2*6)+(1*6)=119
119 % 10 = 9
So 25447-66-9 is a valid CAS Registry Number.
InChI:InChI=1/C32H43N5O5/c1-17(2)12-25-29(39)36-11-7-10-26(36)32(41)37(25)30(40)31(42-32,18(3)4)34-28(38)20-13-22-21-8-6-9-23-27(21)19(15-33-23)14-24(22)35(5)16-20/h6,8-9,15,17-18,20,22,24-26,33,41H,7,10-14,16H2,1-5H3,(H,34,38)/t20-,22-,24-,25+,26+,31-,32+/m1/s1
25447-66-9Relevant articles and documents
Synthesis of European pharmacopoeial impurities A, B, C, and D of cabergoline
Wagger, Jernej,Pozes, Aljaz,Pozgan, Franc
, p. 23146 - 23156 (2013/11/19)
For the use of analytics, European pharmacopoeial impurities A, B, C, and D of cabergoline were synthesized. Ergocryptine was chosen as a starting material and synthesis was accomplished via two approaches, different in length and stereochemical outcome. A longer, indirect approach was realized through otherwise problematic oxidations of the 9,10-dihidrolysergol derivative, to the corresponding aldehyde and carboxylic acid. This was achieved by the use of activated DMSO and a Pinnick oxidation sequence. All four synthesized impurities are used as analytical standards in cabergoline manufacturing processes.